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  1. No Access

    Article

    Ligand-dependent localization and function of ORP–VAP complexes at membrane contact sites

    Oxysterol-binding protein/OSBP-related proteins (ORPs) constitute a conserved family of sterol/phospholipid-binding proteins with lipid transporter or sensor functions. We investigated the spatial occurrence a...

    Marion Weber-Boyvat, Henriikka Kentala… in Cellular and Molecular Life Sciences (2015)

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    Protocol

    Kinetic Activation of Rab8 Guanine Nucleotide Exchange Factor Rabin8 by Rab11

    The Rab family of small GTPases acts as molecular switches that control various stages of vesicular transport. Rab8 functions in exocytic trafficking from the trans-Golgi network (TGN) and recycling endosomes to ...

    Shanshan Feng, Bin Wu, Johan Peränen, Wei Guo in Rab GTPases (2015)

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    Article

    Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures

    A previously uncharacterized member of the I-BAR subfamily of BAR-domain proteins, Pinkbar, is expressed in epithelial cells, where it stabilizes planar membrane sheets. Structural, biochemical and mutagenesis...

    Anette Pykäläinen, Malgorzata Boczkowska… in Nature Structural & Molecular Biology (2011)

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    Article

    A molecular network for de novo generation of the apical surface and lumen

    Polarized-membrane trafficking supports the delivery of polarity proteins to discrete plasma-membrane domains, although the interplay between trafficking and polarity pathways is not fully understood. The smal...

    David M. Bryant, Anirban Datta, Alejo E. Rodríguez-Fraticelli… in Nature Cell Biology (2010)