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Article
Open AccessCorrection: Introducing Braining—physical exercise as adjunctive therapy in psychiatric care: a retrospective cohort study of a new method
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Article
Open AccessIntroducing Braining—physical exercise as adjunctive therapy in psychiatric care: a retrospective cohort study of a new method
Patients with severe mental disorders suffer from higher rates of poor somatic health and have shorter life expectancy than the average population. Physical activity can treat and prevent several diseases, e.g. c...
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Article
Open AccessPublisher Correction: HIF-1 stabilization in T cells hampers the control of Mycobacterium tuberculosis infection
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Article
Open AccessPublisher Correction: Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome
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Article
Open AccessHIF-1 stabilization in T cells hampers the control of Mycobacterium tuberculosis infection
The hypoxia-inducible factors (HIFs) regulate the main transcriptional pathway of response to hypoxia in T cells and are negatively regulated by von Hippel-Lindau factor (VHL). But the role of HIFs in the regu...
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Article
Open AccessImpaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome
Mitochondria are the main consumers of oxygen within the cell. How mitochondria sense oxygen levels remains unknown. Here we show an oxygen-sensitive regulation of TFAM, an activator of mitochondrial transcrip...
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Article
Open AccessAuthor Correction: A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons
In the originally published version of this Article, financial support was not fully acknowledged. The PDF and HTML versions of the Article have now been corrected to include support to Thomas Perlmann provide...
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Article
Open AccessNexilin/NEXN controls actin polymerization in smooth muscle and is regulated by myocardin family coactivators and YAP
Nexilin, encoded by the NEXN gene, is expressed in striated muscle and localizes to Z-discs, influencing mechanical stability. We examined Nexilin/NEXN in smooth muscle cells (SMCs), and addressed if Nexilin loca...
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Article
Open AccessA comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons
The brain is composed of hundreds of different neuronal subtypes, which largely retain their identity throughout the lifespan of the organism. The mechanisms governing this stability are not fully understood, ...
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Article
Open AccessSumoylation of Notch1 represses its target gene expression during cell stress
The Notch signaling pathway is a key regulator of stem cells during development, and its deregulated activity is linked to developmental defects and cancer. Transcriptional activation of Notch target genes req...
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Article
Open AccessPotent pro-inflammatory and pro-fibrotic molecules, osteopontin and galectin-3, are not major disease modulators of laminin α2 chain-deficient muscular dystrophy
A large number of human diseases are caused by chronic tissue injury with fibrosis potentially leading to organ failure. There is a need for more effective anti-fibrotic therapies. Congenital muscular dystroph...
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Chapter and Conference Paper
A Cognitive Systems Engineering Perspective on Fighter Cockpit Design Evaluation
In this paper a method for evaluating fighter aircraft cockpit design solutions is suggested, taking into account the specific needs and limitations that come from working in the context of develo** modern f...
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Article
PKCζ regulates Notch receptor routing and activity in a Notch signaling-dependent manner
Activation of Notch signaling requires intracellular routing of the receptor, but the mechanisms controlling the distinct steps in the routing process is poorly understood. We identify PKCζ as a key regulator ...
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Chapter and Conference Paper
Applied Cognitive Ergonomics Design Principles for Fighter Aircraft
The objective of the reported work was to study the use and applicability of applied cognitive ergonomics design principles for fighter aircraft, with examples from the modern Swedish swing-role aircraft Gripe...
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Article
Open AccessPITX2 gain-of-function induced defects in mouse forelimb development
Limb development and patterning originate from a complex interplay between the skeletal elements, tendons, and muscles of the limb. One of the genes involved in patterning of limb muscles is the homeobox trans...
