5 Result(s)

Article

Publisher Correction: Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome

Shuijie Li, Wenyu Li, Juan Yuan, Petra Bullova, Jieyu Wu, Xuepei Zhang… in Nature Metabolism (2022)

Article

Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome

Mitochondria are the main consumers of oxygen within the cell. How mitochondria sense oxygen levels remains unknown. Here we show an oxygen-sensitive regulation of TFAM, an activator of mitochondrial transcrip...

Shuijie Li, Wenyu Li, Juan Yuan, Petra Bullova, Jieyu Wu, Xuepei Zhang… in Nature Metabolism (2022)

Article

Sumoylation of Notch1 represses its target gene expression during cell stress

The Notch signaling pathway is a key regulator of stem cells during development, and its deregulated activity is linked to developmental defects and cancer. Transcriptional activation of Notch target genes req...

Christian J. M. Antila, Vilma Rraklli, Henri A. Blomster… in Cell Death & Differentiation (2018)

Article

PKCζ regulates Notch receptor routing and activity in a Notch signaling-dependent manner

Activation of Notch signaling requires intracellular routing of the receptor, but the mechanisms controlling the distinct steps in the routing process is poorly understood. We identify PKCζ as a key regulator ...

Marika Sjöqvist, Daniel Antfolk, Saima Ferraris, Vilma Rraklli… in Cell Research (2014)

Article

PITX2 gain-of-function induced defects in mouse forelimb development

Limb development and patterning originate from a complex interplay between the skeletal elements, tendons, and muscles of the limb. One of the genes involved in patterning of limb muscles is the homeobox trans...

Johan Holmberg, Gorel Ingner, Curt Johansson, Peter Leander… in BMC Developmental Biology (2008)