14 Result(s)
within
Joel Schwartz
Biomedicine
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Article
Open AccessDNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function
The difference between an individual's chronological and DNA methylation predicted age (DNAmAge), termed DNAmAge acceleration (DNAmAA), can capture life-long environmental exposures and age-related physiologic...
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Article
Open AccessAnalysis of repeated leukocyte DNA methylation assessments reveals persistent epigenetic alterations after an incident myocardial infarction
Most research into myocardial infarctions (MIs) have focused on preventative efforts. For survivors, the occurrence of an MI represents a major clinical event that can have long-lasting consequences. There has...
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Article
Open AccessShort-term effects of fine particulate matter and ozone on the cardiac conduction system in patients undergoing cardiac catheterization
Air pollution-induced changes in cardiac electrophysiological properties could be a pathway linking air pollution and cardiovascular events. The evidence of air pollution effects on the cardiac conduction syst...
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Article
Open AccessEmpirical comparison of reduced representation bisulfite sequencing and Infinium BeadChip reproducibility and coverage of DNA methylation in humans
We empirically examined the strengths and weaknesses of two human genome-wide DNA methylation platforms: rapid multiplexed reduced representation bisulfite sequencing and Illumina’s Infinium BeadChip. Rapid mu...
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Article
Open AccessProspective changes in global DNA methylation and cancer incidence and mortality
Methylation of repetitive elements Alu and LINE-1 in humans is considered a surrogate for global DNA methylation. Previous studies of blood-measured Alu/LINE-1 and cancer risk are inconsistent.
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Chapter and Conference Paper
Alcohol Metabolism by Oral Streptococci and Interaction with Human Papillomavirus Leads to Malignant Transformation of Oral Keratinocytes
Poor oral hygiene, ethanol consumption, and human papillomavirus (HPV) are associated with oral and esophageal cancers. However, the mechanism is not fully known. This study examines alcohol metabolism in Strepto...
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Article
Open AccessAir pollution exposure and lung function in highly exposed subjects in Bei**g, China: a repeated-measure study
Exposure to ambient particulate matter (PM) has been associated with reduced lung function. Elemental components of PM have been suggested to have critical roles in PM toxicity, but their contribution to respi...
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Article
Open AccessInhalable particulate matter and mitochondrial DNA copy number in highly exposed individuals in Bei**g, China: a repeated-measure study
Mitochondria are both a sensitive target and a primary source of oxidative stress, a key pathway of air particulate matter (PM)-associated diseases. Mitochondrial DNA copy number (MtDNAcn) is a marker of mitoc...
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Chapter
Head and Neck Carcinogenesis a Product of Complex Evolutionary Forces
This chapter explores carcinogenesis of the head and neck as a product of biologic forces present in micro and macroenviroments. We attempt to present dynamic complex characteristics of head and neck tissues i...
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Chapter
Poly-Microbial Interaction with Human Papilloma Virus Leading to Increased Risk for Head and Neck Squamous Cell Carcinoma and Oral Squamous Cell Carcinomas
750 bacterial taxa reside in the oral pharynx and oral cavity with additional populations of fungi and viruses. This initial microbial presence is independent of host inflammatory response and produces a persi...
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Article
Open AccessFolate network genetic variation, plasma homocysteine, and global genomic methylation content: a genetic association study
Sequence variants in genes functioning in folate-mediated one-carbon metabolism are hypothesized to lead to changes in levels of homocysteine and DNA methylation, which, in turn, are associated with risk of ca...
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Article
Repetitive element hypomethylation in blood leukocyte DNA and cancer incidence, prevalence, and mortality in elderly individuals: the Normative Aging Study
Global genomic hypomethylation is a common epigenetic event in cancer that mostly results from hypomethylation of repetitive DNA elements. Case–control studies have associated blood leukocyte DNA hypomethylati...
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Article
Open AccessWeather-based prediction of Plasmodium falciparum malaria in epidemic-prone regions of Ethiopia II. Weather-based prediction systems perform comparably to early detection systems in identifying times for interventions
Timely and accurate information about the onset of malaria epidemics is essential for effective control activities in epidemic-prone regions. Early warning methods that provide earlier alerts (usually by the u...
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Article
Open AccessWeather-based prediction of Plasmodium falciparum malaria in epidemic-prone regions of Ethiopia I. Patterns of lagged weather effects reflect biological mechanisms
Malaria epidemics due to Plasmodium falciparum are reported frequently in the East African highlands with high case fatality rates. There have been formal attempts to predict epidemics by the use of climatic vari...
