15 Result(s)
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Cavin K. Ward-Caviness
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Open AccessSerum metabolite signatures of cardiac function and morphology in individuals from a population-based cohort
Changes in serum metabolites in individuals with altered cardiac function and morphology may exhibit information about cardiovascular disease (CVD) pathway dysregulations and potential CVD risk factors. We aim...
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Open AccessPrescribed fires, smoke exposure, and hospital utilization among heart failure patients
Prescribed fires often have ecological benefits, but their environmental health risks have been infrequently studied. We investigated associations between residing near a prescribed fire, wildfire smoke exposu...
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Open AccessRedefining exposure science to advance research supporting cumulative impacts, environmental justice, and decision-making
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Objectively measured external building quality, Census housing vacancies and age, and serum metals in an adult cohort in Detroit, Michigan
Residentially derived lead pollution remains a significant problem in urban areas across the country and globe. The risks of childhood residence in housing contaminated with lead-based paint are well-establish...
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Open AccessThe association of accelerated epigenetic age with all-cause mortality in cardiac catheterization patients as mediated by vascular and cardiometabolic outcomes
Epigenetic age is a DNA methylation-based biomarker of aging that is accurate across the lifespan and a range of cell types. The difference between epigenetic age and chronological age, termed age acceleration...
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Open AccessSecondary organic aerosol association with cardiorespiratory disease mortality in the United States
Fine particle pollution, PM2.5, is associated with increased risk of death from cardiorespiratory diseases. A multidecadal shift in the United States (U.S.) PM2.5 composition towards organic aerosol as well as ad...
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Open AccessDNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function
The difference between an individual's chronological and DNA methylation predicted age (DNAmAge), termed DNAmAge acceleration (DNAmAA), can capture life-long environmental exposures and age-related physiologic...
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Open AccessEpigenetic predictors of all-cause mortality are associated with objective measures of neighborhood disadvantage in an urban population
Neighborhood characteristics are robust predictors of overall health and mortality risk for residents. Though there has been some investigation of the role that molecular indicators may play in mediating neigh...
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A review of gene-by-air pollution interactions for cardiovascular disease, risk factors, and biomarkers
Air pollution is recognized as causal factor for cardiovascular disease (CVD) and is associated with multiple CVD risk factors. Substantial research effort has been invested in understanding the linkages betwe...
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Open AccessAnalysis of repeated leukocyte DNA methylation assessments reveals persistent epigenetic alterations after an incident myocardial infarction
Most research into myocardial infarctions (MIs) have focused on preventative efforts. For survivors, the occurrence of an MI represents a major clinical event that can have long-lasting consequences. There has...
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Open AccessAutosomal genetic variation is associated with DNA methylation in regions variably esca** X-chromosome inactivation
X-chromosome inactivation (XCI), i.e., the inactivation of one of the female X chromosomes, restores equal expression of X-chromosomal genes between females and males. However, ~10% of genes show variable degr...
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DNA Methylation Age—Environmental Influences, Health Impacts, and Its Role in Environmental Epidemiology
DNA methylation-based aging biomarkers are valuable tools for evaluating the aging process from a molecular perspective. These epigenetic aging biomarkers can be evaluated across the lifespan and are tissue sp...
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Open AccessThe dynamics of smoking-related disturbed methylation: a two time-point study of methylation change in smokers, non-smokers and former smokers
The evidence for epigenome-wide associations between smoking and DNA methylation continues to grow through cross-sectional studies. However, few large-scale investigations have explored the associations using ...
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Open AccessDNA methylation signatures of chronic low-grade inflammation are associated with complex diseases
Chronic low-grade inflammation reflects a subclinical immune response implicated in the pathogenesis of complex diseases. Identifying genetic loci where DNA methylation is associated with chronic low-grade inf...
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Open AccessThe transcriptional landscape of age in human peripheral blood
Disease incidences increase with age, but the molecular characteristics of ageing that lead to increased disease susceptibility remain inadequately understood. Here we perform a whole-blood gene expression met...
