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Article
Open AccessNeuronBridge: an intuitive web application for neuronal morphology search across large data sets
Neuroscience research in Drosophila is benefiting from large-scale connectomics efforts using electron microscopy (EM) to reveal all the neurons in a brain and their connections. To exploit this knowledge base, r...
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Article
Whole-cell organelle segmentation in volume electron microscopy
Cells contain hundreds of organelles and macromolecular assemblies. Obtaining a complete understanding of their intricate organization requires the nanometre-level, three-dimensional reconstruction of whole ce...
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Article
A statistical test for conserved RNA structure shows lack of evidence for structure in lncRNAs
A new method, R-scape, tests whether observed sequence covariation supports a conserved secondary structure in RNA. The program finds no evidence for previously proposed conserved secondary structures in sever...
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Article
Open AccessSkylign: a tool for creating informative, interactive logos representing sequence alignments and profile hidden Markov models
Logos are commonly used in molecular biology to provide a compact graphical representation of the conservation pattern of a set of sequences. They render the information contained in sequence alignments or pro...
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Article
Patterns of somatic mutation in human cancer genomes
Cancers arise owing to mutations in a subset of genes that confer growth advantage. The availability of the human genome sequence led us to propose that systematic resequencing of cancer genomes for mutations ...
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Article
A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer
We examined the coding sequence of 518 protein kinases, ∼1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with distinct...
