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Article
Open AccessA flexible multivariate model for high-dimensional correlated count data
We propose a flexible multivariate stochastic model for over-dispersed count data. Our methodology is built upon mixed Poisson random vectors (Y1,…,Yd), where the {Yi} are conditionally independent Poisson random...
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Article
Open AccessNBIA: a network-based integrative analysis framework – applied to pathway analysis
With the explosion of high-throughput data, effective integrative analyses are needed to decipher the knowledge accumulated in biological databases. Existing meta-analysis approaches in systems biology often f...
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Chapter and Conference Paper
A Graphical Processing Unit Accelerated NORmal to Anything Algorithm for High Dimensional Multivariate Simulation
Many complex real world systems can be represented as correlated high dimensional vectors (up to 20,501 in this paper). While univariate analysis is simpler, it does not account for correlations between variab...
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Article
Open AccessN-of-1-pathways MixEnrich: advancing precision medicine via single-subject analysis in discovering dynamic changes of transcriptomes
Transcriptome analytic tools are commonly used across patient cohorts to develop drugs and predict clinical outcomes. However, as precision medicine pursues more accurate and individualized treatment decisions...
