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Article
Open AccessA liquid biopsy signature of circulating extracellular vesicles-derived RNAs predicts response to first line chemotherapy in patients with metastatic colorectal cancer
Colorectal cancer (CRC) is one of the most threatening tumors in the world, and chemotherapy remains dominant in the treatment of metastatic CRC (mCRC) patients. The purpose of this study was to develop a biom...
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Article
Open AccessIntegrated DNA and RNA sequencing reveals early drivers involved in metastasis of gastric cancer
Gastric cancer (GC) is the second cause of cancer-related death and metastasis is an important cause of death. Considering difficulties in searching for metastatic driver mutations, we tried a novel strategy h...
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Article
Open AccessValue of gamma interferon enzyme-linked immunospot assay in the diagnosis of peritoneal dialysis-associated tuberculous peritonitis
Tuberculous peritonitis is the most common form of extrapulmonary tuberculosis infection in peritoneal dialysis patients. However, diagnosing tuberculous peritonitis quickly and early has always been a challen...
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Article
Open AccessThe polycomb group protein EZH2 induces epithelial–mesenchymal transition and pluripotent phenotype of gastric cancer cells by binding to PTEN promoter
The influences of oncogenic Ezh2 on the progression and prognosis of gastric cancer (GC) and the underlying mechanisms are still poorly understood. Here, we aimed at investigating clinicopathological significa...
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Article
A comparison of disease severity measurements using image analysis and visual estimates using a category scale for genetic analysis of resistance to bacterial spot in tomato
Bacterial spot caused by several Xanthomonas spp. is an economically important disease of tomato (Solanum lycopersicum L.). Host resistance to the disease is partially dominant or incomplete, which requires accur...
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Article
Fine map** and analysis of a candidate gene in tomato accession PI128216 conferring hypersensitive resistance to bacterial spot race T3
Bacterial spot caused by Xanthomonas euvesicatoria, X. vesicatoria, X. perforans and X. gardneri is one of the most destructive diseases in tomatoes (Solanum lycopersicum L.) growing in tropical and subtropical r...
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Article
Open AccessAn SNP selection strategy identified IL-22 associating with susceptibility to tuberculosis in Chinese
Recent studies showed that IL-22 plays a protective role in the host defense. However, the contribution of polymorphisms of the IL-22 gene to human TB susceptibility remains untested. We have designed a comput...
