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  1. Article

    Open Access

    Dual-loss of PBRM1 and RAD51 identifies hyper-sensitive subset patients to immunotherapy in clear cell renal cell carcinoma

    Homologous recombination deficiency (HRD), though largely uncharacterized in clear cell renal cell carcinoma (ccRCC), was found associated with RAD51 loss of expression. PBRM1 is the second most common mutated...

    Ziyang Xu, Wenbin Jiang, Li Liu, Youqi Qiu, Jiahao Wang… in Cancer Immunology, Immunotherapy (2024)

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  2. No Access

    Article

    Immune inactivation by neuropilin-1 predicts clinical outcome and therapeutic benefit in muscle-invasive bladder cancer

    Immune checkpoint blockade (ICB) and adjuvant chemotherapy (ACT) have shown clinical benefit in muscle-invasive bladder cancer (MIBC) with only a few predictive biomarkers identified so far. Neuropilin-1 (NRP1...

    Yanze Yu, Han Zeng, Kaifeng **, Runze You, Zhaopei Liu… in Cancer Immunology, Immunotherapy (2022)

  3. No Access

    Article

    Infiltration and Polarization of Tumor-associated Macrophages Predict Prognosis and Therapeutic Benefit in Muscle-Invasive Bladder Cancer

    Muscle-invasive bladder cancer (MIBC) is an aggressive and heterogeneous malignancy. Tumor-associated macrophages (TAMs) are key infiltrating cell populations in the inflammatory microenvironment of malignant ...

    Mengmeng Sun, Han Zeng, Kaifeng **, Zhaopei Liu… in Cancer Immunology, Immunotherapy (2022)

  4. No Access

    Article

    Latency-associated peptide identifies therapeutically resistant muscle-invasive bladder cancer with poor prognosis

    Latency-associated peptide (LAP) was identified as crucial immune regulator in tumor microenvironment (TME) in recent researches. In this study, we aimed to estimate the predictive value of LAP expression for ...

    Ruiting Ye, Han Zeng, Zhaopei Liu, Kaifeng **… in Cancer Immunology, Immunotherapy (2022)

  5. No Access

    Article

    CCR8 blockade primes anti-tumor immunity through intratumoral regulatory T cells destabilization in muscle-invasive bladder cancer

    Regulatory T cells (Tregs) play a major role in the development of an immunosuppressive tumor microenvironment. Systemic Treg depletion is not favored because of the critical role of Tregs in maintaining immun...

    Tao Wang, Quan Zhou, Han Zeng, Hongyu Zhang… in Cancer Immunology, Immunotherapy (2020)

  6. No Access

    Article

    Tumor-infiltrating CD39+CD8+ T cells determine poor prognosis and immune evasion in clear cell renal cell carcinoma patients

    Tumor microenvironment is important in the progression of clear cell renal cell carcinoma (ccRCC), and its prognostic value is still unclear. Recent reports demonstrated tumor-infiltrating CD39+CD8+ T cells are a...

    Yu Qi, Yu **a, Zhiyuan Lin, Yang Qu, Yangyang Qi… in Cancer Immunology, Immunotherapy (2020)

  7. No Access

    Article

    Lauren classification identifies distinct prognostic value and functional status of intratumoral CD8+ T cells in gastric cancer

    With dichotomous etiology and pathogenesis, intestinal type and diffuse type gastric cancers vary in their clinical and molecular features to the point of representing distinct entities. However, the differenc...

    Ruochen Li, Heng Zhang, Yifan Cao, **n Liu, Yifan Chen… in Cancer Immunology, Immunotherapy (2020)

  8. No Access

    Article

    Tumor-associated macrophages expressing galectin-9 identify immunoevasive subtype muscle-invasive bladder cancer with poor prognosis but favorable adjuvant chemotherapeutic response

    Tumor-associated macrophages (TAMs) exist as heterogeneous subsets and have dichotomous roles in cancer-immune evasion. This study aims to assess the clinical effects of Galectin-9+ tumor-associated macrophages (...

    Yangyang Qi, Yuan Chang, Zewei Wang, Lingli Chen… in Cancer Immunology, Immunotherapy (2019)

  9. No Access

    Article

    Tumor infiltrating mast cells determine oncogenic HIF-2α-conferred immune evasion in clear cell renal cell carcinoma

    Hypoxia-inducible factor 2α (HIF-2α) overexpression leads to activation of angiogenic pathways. However, little is known about the association between HIF-2α expression and anti-tumor immunity in clear cell re...

    Ying **ong, Li Liu, Yu **a, Yangyang Qi, Yifan Chen… in Cancer Immunology, Immunotherapy (2019)

  10. No Access

    Article

    CD19+ tumor-infiltrating B-cells prime CD4+ T-cell immunity and predict platinum-based chemotherapy efficacy in muscle-invasive bladder cancer

    CD19+ tumor-infiltrating B-cells (CD19+ TIB) play a crucial role in tumorigenesis, but their clinical relevance in muscle-invasive bladder cancer (MIBC) remains unknown. This study aimed to investigate the progno...

    Qi Jiang, Qiang Fu, Yuan Chang, Zheng Liu, Junyu Zhang… in Cancer Immunology, Immunotherapy (2019)

  11. No Access

    Article

    CXCL13 expression is prognostic and predictive for postoperative adjuvant chemotherapy benefit in patients with gastric cancer

    Chemokine (C-X-C motif) ligand 13 (CXCL13/BLC/BCA-1) is a cytokine from C-X-C chemokine family, which is selectively chemotactic for B cells. Previous research has demonstrated that high CXCL13 expression is c...

    Yichou Wei, Chao Lin, He Li, Zhiying Xu, Jieti Wang… in Cancer Immunology, Immunotherapy (2018)

  12. No Access

    Article

    HLA class I expression predicts prognosis and therapeutic benefits from tyrosine kinase inhibitors in metastatic renal-cell carcinoma patients

    Classical HLA class I antigen is highly involved in antigen presentation and adaptive immune response against tumor. In this study, we explored its predictive value for treatment response and survival in metas...

    Jiajun Wang, Li Liu, Yang Qu, Wei **, Yu **a, Qi Bai… in Cancer Immunology, Immunotherapy (2018)