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  1. No Access

    Article

    Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors

    Angiogenesis depends on vascular endothelial growth factor (VEGF) for initiation and platelet-derived growth factor (PDGF) for maintenance of blood vessels. We have designed a targeted library of compounds fro...

    Jiazhi Sun, De-an Wang, Rishi K Jain, Adam Carie, Steve Paquette, Eileen Ennis… in Oncogene (2005)

  2. No Access

    Article

    Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity

    Constitutive activation of the JAK/STAT3 pathway is a major contributor to oncogenesis. In the present study, structure–activity relationship (SAR) studies with five cucurbitacin (Cuc) analogs, A, B, E, I, and...

    Jiazhi Sun, Michelle A Blaskovich, Richard Jove, Sandra K Livingston… in Oncogene (2005)

  3. No Access

    Article

    Inhibition of Angiogenesis by Aβ Peptides

    Aβ peptides are naturally occurring peptides forming β-sheet aggregates that constitute an integral component of senile plaques and vascular deposits in Alzheimer's disease. Since several peptides adopting a β-sh...

    Daniel Paris, Kirk Townsend, Amita Quadros, James Humphrey, Jiazhi Sun… in Angiogenesis (2004)

  4. No Access

    Article

    Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts

    The ability of Ras oncoproteins to cause malignant transformation requires their post-translational modifications by prenyl groups. Because K-Ras can be both farnesylated and geranylgeranylated it is not known...

    Jiazhi Sun, Yimin Qian, Andrew D Hamilton, Saïd M Sebti in Oncogene (1998)