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Article
Open AccessIdentification of shared pathogenetic mechanisms between COVID-19 and IC through bioinformatics and system biology
COVID-19 increased global mortality in 2019. Cystitis became a contributing factor in SARS-CoV-2 and COVID-19 complications. The complex molecular links between cystitis and COVID-19 are unclear. This study in...
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Article
Open AccessGss deficiency causes age-related fertility impairment via ROS-triggered ferroptosis in the testes of mice
Glutathione synthetase (GSS) catalyzes the final step in the synthesis of glutathione (GSH), a well-established antioxidant. Research on the specific roles of the Gss gene during spermatogenesis remains limited d...
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Article
Fabrication of Dual-Functional Micelles Based on Star-Shaped Copolymer for Bioimaging
Dual-modal fluorescent/magnetic resonance imaging attracts more and more attentions in biomedical applications. Herein, star-shaped poly(ε-caprolactone)-b-poly(N-vinylpyrrolidone) amphiphilic copolymer with a tet...
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Article
Open AccessSmooth muscle liver kinase B1 inhibits foam cell formation and atherosclerosis via direct phosphorylation and activation of SIRT6
Foam cell formation is a hallmark of the early phase of atherosclerosis. Growing evidence has demonstrated that vascular smooth muscle cells (VSMCs) comprise a considerable proportion of foam cells. Liver kina...
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Article
Iron-Mediated AGET ATRP of Methyl Methacrylate in Green Polar Ethyl Lactate Solvent without any External Ligand
In this paper, ethyl lactate was used as a green solvent for iron(III)-catalyzed activators generated by electron transfer atom transfer radical polymerizations of methyl methacrylate in the absence of any ext...
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Article
Open AccessRhoGDIα regulates spermatogenesis through Rac1/cofilin/F-actin signaling
Spermatogenesis is an extremely complex process, and any obstruction can cause male infertility. RhoGDIα has been identified as a risk of male sterility. In this study, we generate RhoGDIα knockout mice, and find...
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Article
One-Step Regulatory Synthesis of Quaternary Transition Metal Sulfide Cu2MnSnS4 as Electrode Material for High-Performance Supercapacitors
Multiple transition metal sulfides (TMSs) have been extensively studied as electrode materials for supercapacitors (SCs) due to their advantages such as high capacitance and good stability. However, improving ...
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Article
Constructing accommodational space in MnO2 cathode for Mn2+ transport and electrodeposition for aqueous zinc-ion batteries
MnO2 is the most desirable cathode material for aqueous zinc ion batteries; however, its electrochemical performance is still limited by the problem of structural collapse that inevitably occurs due to the dissol...
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Article
Grafting polyisoprene onto surfaces of kaolin by spray drying technology and modification of styrene–butadiene rubber
In this contribution, we reported the investigation of styrene–butadiene rubber (SBR) reinforced by kaolin-graft-polyisoprene (Mkaol). First, poly(isoprene-maleic anhydride) random copolymers (PIPMA) which was us...
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Article
Open AccessComprehensive molecular evaluation of the histone methyltransferase gene family and their important roles in two-line hybrid wheat
Histone methylation usually plays important roles in plant development through post-translational regulation and may provide a new visual field for heterosis. The histone methyltransferase gene family has been...
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Article
Deficiency of Klc2 Induces Low-Frequency Sensorineural Hearing Loss in C57BL/6 J Mice and Human
The transport system in cochlear hair cells (HCs) is important for their function, and the kinesin family of proteins transports numerous cellular cargos via the microtubule network in the cytoplasm. Here, we ...
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Article
Sunway supercomputer architecture towards exascale computing: analysis and practice
In recent years, the improvements of system performance and energy efficiency for supercomputers have faced increasing challenges, which create more intensive demands on the architecture design for realizing e...
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Article
Tprn is essential for the integrity of stereociliary rootlet in cochlear hair cells in mice
Tprn encodes the taperin protein, which is concentrated in the tapered region of hair cell stereocilia in the inner ear. In humans, TPRN mutations cause autosomal recessive nonsyndromic deafness (DFNB79) by an un...
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Article
Strength Prediction of a Single Tooth Bound to Composite Pre-tightened Tooth Connection (PTTC) Joints based on Different Failure Criteria
A method capable to predict the strength of single tooth bound to composite pre-tightened tooth connection (PTTC) joints is presented. The proposed method uses four representative failure criteria: max-stress,...
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Article
Nigericin inhibits epithelial ovarian cancer metastasis by suppressing the cell cycle and epithelial−mesenchymal transition
Epithelial ovarian cancer (EOC) has the highest mortality among various types of gynecological malignancies. Most patients die of metastasis and recurrence due to cisplatin resistance. Thus, it is urgent to de...
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Article
Highly efficient removal of copper ions from water using poly(acrylic acid)-grafted chitosan adsorbent
Biodegradable and ultrahigh content grafted chitosan-g-poly(acrylic acid) powder was successfully synthesized in a homogeneous system and used as adsorbents for the removal of Cu(II) in aqueous solution. The c...
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Article
Loss of liver kinase B1 causes planar polarity defects in cochlear hair cells in mice
The tumor suppressor gene liver kinase B1 (LKB1), also called STK11, encodes a serine/threonine kinase. LKB1 plays crucial roles in cell differentiation, proliferation, and polarity. In this study, LKB1 condit...
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Article
Open AccessLoss of Lysyl Oxidase-like 3 Attenuates Embryonic Lung Development in Mice
Lysyl oxidase-like 3 (LOXL3), a human disease gene candidate, is a member of the lysyl oxidase (LOX) family and is indispensable for mouse palatogenesis and vertebral column development. Our previous study sho...
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Article
Open AccessDeletion of Brg1 causes abnormal hair cell planer polarity, hair cell anchorage, and scar formation in mouse cochlea
Hair cells (HCs) are mechanosensors that play crucial roles in perceiving sound, acceleration, and fluid motion. The precise architecture of the auditory epithelium and its repair after HC loss is indispensabl...
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Article
Open AccessComprehensive analyses of the annexin gene family in wheat
Annexins are an evolutionarily conserved multigene family of calcium-dependent phospholipid binding proteins that play important roles in stress resistance and plant development. They have been relatively well...
