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Article
Open AccessTwo nomograms constructed for predicting the efficacy and prognosis of advanced non‑small cell lung cancer patients treated with anti‑PD‑1 inhibitors based on the absolute counts of lymphocyte subsets
Patients treated with immune checkpoint inhibitors (ICIs) are at risk of considerable adverse events, and the ongoing struggle is to accurately identify the subset of patients who will benefit. Lymphocyte subs...
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Article
Open AccessEnhanced response of soil respiration to experimental warming upon thermokarst formation
As global temperatures continue to rise, a key uncertainty of terrestrial carbon (C)–climate feedback is the rate of C loss upon abrupt permafrost thaw. This type of thawing—termed thermokarst—may in turn acce...
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Article
Open AccessCorrection: OTUB2 regulates KRT80 stability via deubiquitination and promotes tumour proliferation in gastric cancer
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Article
Open AccessPrognostic significance of blood-based PD-L1 analysis in patients with non-small cell lung cancer undergoing immune checkpoint inhibitor therapy: a systematic review and meta-analysis
The main types of PD-L1 in the blood include soluble PD-L1 (sPD-L1), exosomal PD-L1 (exoPD-L1), and PD-L1 in circulating tumor cells (CTCs). However, the predictive and prognostic values of these three indicat...
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Article
Open AccessPerioperative chemotherapy versus adjuvant chemotherapy treatment for resectable locally advanced gastric cancer: a retrospective cohort study
Neoadjuvant chemotherapy (NAC) is increasingly used in locally advanced gastric cancer (LAGC), but the clinical safety and efficacy are still controversial. This study aims to compare perioperative chemotherap...
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Article
Open AccessIdentification of SPRYD4 as a tumour suppressor predicts prognosis and correlates with immune infiltration in cholangiocarcinoma
Cholangiocarcinoma (CCA) is an aggressive solid tumour with a 5-year survival rate ranging from 7% to 20%. It is, therefore, urgent to identify novel biomarkers and therapeutic targets to improve the outcomes ...
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Article
Open AccessDoes postoperative chemotherapy improve overall survival of patients with ypT1-2N0 cancer?
Perioperative chemotherapy combined with curative gastrectomy has been increasingly represented the standard therapeutic strategy for resectable gastric cancer (GC). However, it is still unclear whether postop...
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Article
Open AccessCrosstalk between tumor-associated macrophages and tumor cells promotes chemoresistance via CXCL5/PI3K/AKT/mTOR pathway in gastric cancer
5-fluorouracil (5-FU)-based chemotherapy regimen has been widely used for the treatment of gastric cancer, but meanwhile the development of chemotherapeutic resistance remains a major clinical challenge. Tumor...
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Article
Open AccessCorrection: OTUB2 regulates KRT80 stability via deubiquitination and promotes tumour proliferation in gastric cancer
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Article
Open AccessOTUB2 regulates KRT80 stability via deubiquitination and promotes tumour proliferation in gastric cancer
OTUB2 is a deubiquitinating enzyme that contributes to tumor progression. However, the expression of OTUB2 and its prognostic importance in gastric cancer remain unclear. The expression of OTUB2 and KRT80 in G...
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Article
Open AccessLow urinary iodine is a protective factor of central lymph node metastasis in papillary thyroid cancer: a cross-sectional study
An abrupt increase of thyroid cancer has been witnessed paralleling the supplemented iodine intake in formerly iodine-deficient countries. And increased iodine intake has been linked to the rising incidence ra...
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Article
Open AccessClinicopathological factors affecting the effect of neoadjuvant chemotherapy in patients with gastric cancer
Neoadjuvant chemotherapy is an important part of the comprehensive treatment of advanced gastric cancer (GC). The effect of neoadjuvant chemotherapy plays a key role in the prognosis of GC patients. Pathologic...
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Article
Open AccessWhen to Introduce Three-Dimensional Visualization Technology into Surgical Residency: A Randomized Controlled Trial
Three-dimensional (3D) reconstructed images have been increasingly applied for medical education. Although many studies have described the benefits of such applications, the best time to introduce 3D technolog...
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Article
Open AccessNitrogen availability regulates topsoil carbon dynamics after permafrost thaw by altering microbial metabolic efficiency
Input of labile carbon may accelerate the decomposition of existing soil organic matter (priming effect), with the priming intensity depending on changes in soil nitrogen availability after permafrost thaw. Ho...
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Article
Open AccessStaging laparoscopy for locally advanced gastric cancer in Chinese patients: a multicenter prospective registry study
Staging laparoscopy(SL) is a recommended technique for the staging of Gastric Cancer(GC) and provides the indication for a radical surgery. Considering the medical practice in China, the standardized and regul...
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Article
Open AccessAcupuncture for patients with mild to moderate Alzheimer’s disease: a randomized controlled trial
Alzheimer’s disease (AD) is the most common cause of dementia. However, none of medical treatment can stop or reverse the underlying neurodegenerative of AD at present. Acupuncture has attracted more and more ...
