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Article
Open AccessTransarterial chemoembolization with/without immune checkpoint inhibitors plus tyrosine kinase inhibitors for unresectable hepatocellular carcinoma: a single center, propensity score matching real-world study
To explore the efficacy and safety of Transarterial chemoembolization (TACE) in combination with immune checkpoint inhibitors (ICIs) and tyrosine kinase inhibitors (TKIs) in patients with unresectable hepatoce...
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Article
Investigation on the characteristics of a high-frequency two-dimensional rotary valve generating fluid pulse width modulation wave
Inspired by the working principle that there is no throttling loss (theoretically) in the fully open and fully closed states of high-speed on–off valves, a high-frequency two-dimensional rotary valve is propos...
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Article
Mechanical efficiency of cartridge two-dimensional (2D) piston pump for electro-hydrostatic actuators
The cartridge two-dimensional (2D) piston pump studied is the core component of an aircraft electro-hydrostatic actuator (EHA). Its mechanical efficiency is a very important performance which is closely relate...
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Article
Investigation on a novel high frequency two-dimensional (2D) rotary valve variable mechanism for fluid pulse-width-modulation application
In the traditional valve controlled hydraulic system, flow control is realized by changing the orifice area of the control valve, which inevitably leads to throttling loss. However, the high-speed on-off valve...
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Article
Open AccessLossless enrichment of trace analytes in levitating droplets for multiphase and multiplex detection
Concentrating a trace amount of molecules from liquids, solid objects, or the gas phase and delivering them to a localized area are crucial for almost any trace analyte detection device. Analytes within a liqu...
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Article
Ultra-stable and color-tunable manganese ions doped lead-free cesium zinc halides nanocrystals in glasses for light-emitting applications
All inorganic CsPbX3 (X = Cl, Br, and I) perovskite nanocrystals have made unprecedented radical progresses for opto-electronic applications, but their instability and toxicity of lead impede their wide applicati...
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Article
Open AccessAnalytical Modelling and Experiment of Novel Rotary Electro-Mechanical Converter with Negative Feedback Mechanism for 2D Valve
The manufacturing of spiral groove structure of two-dimensional valve (2D valve) feedback mechanism has shortcomings of both high cost and time-consuming. This paper presents a novel configuration of rotary el...
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Article
Open AccessHOTAIR/miR-1277-5p/ZEB1 axis mediates hypoxia-induced oxaliplatin resistance via regulating epithelial-mesenchymal transition in colorectal cancer
The hypoxic microenvironment contributes to the chemoresistance of many malignant tumors including colorectal cancer (CRC). Accumulating studies have indicated that long non-coding RNAs (lncRNAs) play importan...
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Article
Open AccessThe emerging role of ubiquitin-specific protease 20 in tumorigenesis and cancer therapeutics
As a critical member of the ubiquitin-specific proteolytic enzyme family, ubiquitin-specific peptidase 20 (USP20) regulates the stability of proteins via multiple signaling pathways. In addition, USP20 upregul...
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Article
Open AccessModulation of the tumour microenvironment in hepatocellular carcinoma by tyrosine kinase inhibitors: from modulation to combination therapy targeting the microenvironment
Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide. Tyrosine kinase inhibitors (TKIs) remain the backbone of systematic therapy for advanced hepatocellular carcinoma. Sorafeni...
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Article
Depiction of the genomic and genetic landscape identifies CCL5 as a protective factor in colorectal neuroendocrine carcinoma
Colorectal neuroendocrine carcinomas (CRNECs) are highly aggressive tumours with poor prognosis and low incidence. To date, the genomic landscape and molecular pathway alterations have not been elucidated.
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Article
Open AccessMyeloma-specific superenhancers affect genes of biological and clinical relevance in myeloma
Multiple myeloma (MM) is an aggressive plasma cell neoplasm characterized by genomic heterogeneity. Superenhancers (SEs) are defined as large clusters of enhancers in close genomic proximity, which regulate ge...
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Article
Open AccessEpidemiological trends of tracheal, bronchus, and lung cancer at the global, regional, and national levels: a population-based study
Investigations of disease incidence, mortality, and disability-adjusted life years (DALYs) are valuable for facilitating preventive measures and health resource planning. We examined the tracheal, bronchus, an...
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Article
Open AccessThe Family of Peanut Fatty Acid Desaturase Genes and a Functional Analysis of Four ω-3 AhFAD3 Members
The synthesis of α-linolenic acid (ALA) requires the activity of ω-3 fatty acid desaturases (ω-3 FADs). The quality of peanut oil would be much improved if the content of ALA could be increased. A scan of the ...
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Article
Open AccessFOXC2 is a prognostic biomarker and contributes to the growth and invasion of human hepatocellular carcinoma
Forkhead box C2 (FOXC2) is a crucial factor involving in various cancers. However, its functions in hepatocellular carcinoma (HCC) is unknown. Here, we explored the role of FOXC2 in the progression of HCC and ...
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Article
Study of flow ripple characteristics in an innovative two-dimensional fuel piston pump
To meet the requirements of fuel pumps with high efficiency, high power density, and low flow ripple for modern advanced aircraft, we hereby propose a two-dimensional piston pump (called 2D pump). A single pis...
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Article
Modelling and validation of a roller-cam rail mechanism used in a 2D piston pump
The 2D principle is a new concept in hydrostatic pump design. It features a piston with a compound motion of both rotation and reciprocation to realize the functions of pum** and distribution. The compound m...
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Article
Open AccessTranscriptome analysis of alternative splicing in peanut (Arachis hypogaea L.)
Alternative splicing (AS) represents a mechanism widely used by eukaryotes for the post-transcriptional regulation of genes. The detailed exploration of AS in peanut has not been documented.
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Article
A specialized code for operation transient analysis and its application in fluoride salt-cooled high-temperature reactors
Fluoride salt-cooled high-temperature reactors (FHRs) include many attractive features, such as high temperature, large heat capacity, low pressure and strong inherent safety. Transient characteristics of FHR...
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Article
Open AccessMiR-661 promotes tumor invasion and metastasis by directly inhibiting RB1 in non small cell lung cancer
Aberrant microRNA expression has been implicated in metastasis of cancers. MiR-661 accelerates proliferation and invasion of breast cancer and ovarian cancer, while impedes that of glioma. Its role in non smal...
