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Article
Open AccessDNA methylation landscape in pregnancy-induced hypertension: progress and challenges
Gestational hypertension (PIH), especially pre-eclampsia (PE), is a common complication of pregnancy. This condition poses significant risks to the health of both the mother and the fetus. Emerging evidence su...
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Article
AMPK Regulates M1 Macrophage Polarization through the JAK2/STAT3 Signaling Pathway to Attenuate Airway Inflammation in Obesity-Related Asthma
Abstract—Obesity-related asthma is primarily characterized by nonallergic inflammation, with pathogenesis involving oxidative stress, metabolic imbalance, and immunoinflammatory mechanisms. M1 macrophages, which...
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Article
Open AccessRisk factor analysis and nomogram for predicting poor symptom control in smoking asthmatics
Smoking induces and modifies the airway immune response, accelerating the decline of asthmatics’ lung function and severely affecting asthma symptoms’ control level. To assess the prognosis of asthmatics who s...
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Article
Type I/II Immune Balance Contributes to the Protective Effect of AIF-1 on Hepatic Immunopathology Induced by Schistosoma japonicum in a Transgenic Mouse Model
Schistosomiasis is the second most debilitating neglected tropical disease in the world. Liver egg granuloma and fibrosis are the main damage of schistosomiasis. In this study, the role of allograft inflammato...
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Article
Open AccessExpression of USP25 associates with fibrosis, inflammation and metabolism changes in IgG4-related disease
IgG4-related disease (IgG4-RD) has complex clinical manifestations ranging from fibrosis and inflammation to deregulated metabolism. The molecular mechanisms underpinning these phenotypes are unclear. In this ...
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Article
Open AccessEffect of the BMPR-II-SMAD3/MRTF pathway on proliferation and migration of ASMCs and the mechanism in asthma
A variety of smooth muscle-specific genes and proteins, including SMAD3, BMPR-II, and MRTF, are involved in airway remodeling in asthma. As a receptor of bone morphogenetic protein (BMP) signaling, BMPR-II has...
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Chapter and Conference Paper
Pix2Surf: Learning Parametric 3D Surface Models of Objects from Images
We investigate the problem of learning to generate 3D parametric surface representations for novel object instances, as seen from one or more views. Previous work on learning shape reconstruction from multiple...
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Article
Author Correction: Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses
Macrophages are activated during microbial infection to coordinate inflammatory responses and host defense. Here we find that in macrophages activated by bacterial lipopolysaccharide (LPS), mitochondrial glyce...
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Chapter and Conference Paper
Orientation Adaptive YOLOv3 for Object Detection in Remote Sensing Images
Object detection in remote sensing images is full of challenges. The large scale of detection region, and the difficulty of dense object detection are the main problems needed to solve. Although YOLOv3 perform...
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Article
Open AccessEnhanced Wnt Signalling in Hepatocytes is Associated with Schistosoma japonicum Infection and Contributes to Liver Fibrosis
Liver fibrosis is the most serious pathology caused by Schistosoma japonicum infection, which arises when schistosome eggs are deposited in the liver. Eosinophils, macrophages and hepatic stellate cells (HSCs) ha...
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Article
Interleukin-33 promotes Th2 immune responses in infected mice with Schistosoma japonicum
IL-33, a new member of the IL-1 cytokine family, is associated with many infectious diseases. IL-33 not only is crucial for induction of Th2 polarized responses, but also is involved in induction of inflammati...
