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  1. Article

    Open Access

    DOK3 maintains intestinal homeostasis by suppressing JAK2/STAT3 signaling and S100a8/9 production in neutrophils

    How pathogenesis of inflammatory bowel disease (IBD) depends on the complex interplay of host genetics, microbiome and the immune system is not fully understood. Here, we showed that Downstream of Kinase 3 (DO...

    Jia Tong Loh, Koon-Guan Lee, Alison P. Lee, Joey Kay Hui Teo… in Cell Death & Disease (2021)

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    Article

    The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin

    Ezh2 is a protein methylase that epigenetically modifies chromatin. Su and colleagues identify a cytoplasmic role for Ezh2 whereby it controls the extravasation of innate leukocytes through methylation of tali...

    Merry Gunawan, Nandini Venkatesan, Jia Tong Loh, Jong Fu Wong… in Nature Immunology (2015)