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  1. Article

    Open Access

    Engineering tumor-colonizing E. coli Nissle 1917 for detection and treatment of colorectal neoplasia

    Bioengineered probiotics enable new opportunities to improve colorectal cancer (CRC) screening, prevention and treatment. Here, first, we demonstrate selective colonization of colorectal adenomas after oral de...

    Candice R. Gurbatri, Georgette A. Radford, Laura Vrbanac… in Nature Communications (2024)

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  2. Article

    Open Access

    Loss of Grem1-lineage chondrogenic progenitor cells causes osteoarthritis

    Osteoarthritis (OA) is characterised by an irreversible degeneration of articular cartilage. Here we show that the BMP-antagonist Gremlin 1 (Grem1) marks a bipotent chondrogenic and osteogenic progenitor cell pop...

    Jia Q. Ng, Toghrul H. Jafarov, Christopher B. Little… in Nature Communications (2023)

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  3. Article

    Open Access

    Delineating proinflammatory microenvironmental signals by ex vivo modeling of the immature intestinal stroma

    The intestinal stroma provides an important microenvironment for immune cell activation. The perturbation of this tightly regulated process can lead to excessive inflammation. We know that upregulated Toll-lik...

    Mari Ichinose, Nobumi Suzuki, Tongtong Wang, Josephine A. Wright… in Scientific Reports (2021)

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