-
Article
Novel Mutation in the Moesin (MSN) Gene Leads to Immunodeficiency with Epstein–Barr Virus (EBV) Infection and Dermatomyositis-Like Symptoms
Moesin (MSN) deficiency is a recently reported combined immunodeficiency, and few cases have been reported to date. We describe a Chinese patient with a novel mutation causing MSN deficiency and a novel phenot...
-
Article
Open AccessPhenotypic and Immunological Characterization of Patients with Activated PI3Kδ Syndrome 1 Presenting with Autoimmunity
Autoimmunity is a significant feature of APDS1 patients. We aimed to explore the pathogenic immune phenotype and possible mechanisms of autoimmunity in APDS1 patients.
-
Article
Open AccessNintedanib administration after the onset of acute exacerbation of interstitial lung disease in the real world
Nintedanib reduces the decline in forced vital capacity and extends the time to the first acute exacerbation of interstitial lung disease (AE-ILD). However, the effect of additional nintedanib administration a...
-
Article
Inhibition of NF-κB Signaling-Mediated Crosstalk Between Macrophages and Preosteoblasts by Metformin Alleviates Trauma-Induced Heterotopic Ossification
Heterotopic ossification (HO) is a pathological condition that occurs in soft tissues following severe trauma. The exact pathogenesis of HO remains unclear. Studies have shown that inflammation predisposes pat...
-
Article
Open AccessNomogram for Predicting Early Mortality after Umbilical Cord Blood Transplantation in Children with Inborn Errors of Immunity
Pediatric patients with inborn errors of immunity (IEI) undergoing umbilical cord blood transplantation (UCBT) are at risk of early mortality. Our aim was to develop and validate a prediction model for early m...
-
Article
Clinical and Genetic Characteristics of BCG Disease in Chinese Children: a Retrospective Study
Summarize the characteristics of a large cohort of BCG disease and compare differences in clinical characteristics and outcomes among different genotypes and between primary immunodeficiency disease (PID) and ...
-
Article
Open AccessDeep learning-based prediction of mandibular growth trend in children with anterior crossbite using cephalometric radiographs
It is difficult for orthodontists to accurately predict the growth trend of the mandible in children with anterior crossbite. This study aims to develop a deep learning model to automatically predict the mandi...
-
Article
Open AccessVariant Type X91+ Chronic Granulomatous Disease: Clinical and Molecular Characterization in a Chinese Cohort
We aimed to report the clinical and immunological characteristics of variant type X91+ chronic granulomatous disease (CGD) in a Chinese cohort.
-
Article
The nonlinear effect of financial literacy on wealth: evidence from Germany
This paper investigates the nonlinearity in the relationship of financial literacy and wealth and addresses the potentially inadequate measurement of financial literacy. Using data from the Panel on Household ...
-
Article
Open AccessChromosomal abnormalities related to fever of unknown origin in a Chinese pediatric cohort and literature review
Fever of unknown origin (FUO) has been difficult to diagnose in pediatric clinical practice. With the gradual change in the disease spectrum, genetic factors have received increasing attention. Limited studies...
-
Article
Open AccessReduced frequencies of Foxp3+GARP+ regulatory T cells in COPD patients are associated with multi-organ loss of tissue phenotype
Expression of glycoprotein A dominant repeat (GARP) has been reported to occur only in activated human naturally occurring regulatory T cells (Tregs) and their clones, and not in activated effector T cells, in...
-
Article
Exchange Rate Regimes and Business Cycle Synchronization
This paper studies the effect of seven types of exchange rate regimes on business cycle synchronization, by using a new dataset on bilateral de-facto exchange rate regimes for the 1973-2016 period. Using the extr...
-
Article
Open AccessDynamic alterations in the lung microbiota in a rat model of lipopolysaccharide-induced acute lung injury
The lung microbiota have been found to be substantially altered in numerous pulmonary disorders, and crosstalk between the host pathophysiology and lung microbiota plays critical roles in the regulation of dis...
-
Article
Open AccessEfficacy of tocilizumab therapy in a patient with severe pancytopenia associated with a STAT3 gain-of-function mutation
We aimed to report the clinical characteristics, immunological features, and treatment of one patient with a de novo STAT3 gain-of-function mutation identified by next generation sequencing. We investigated th...
-
Article
Revisiting the trade effects of the euro: data sources and various samples
New evidence in the literature on trade effects of the euro often reports different estimates. In this paper, I investigate the impact of trade data, instead of methodology, on the estimation of the key coeffi...
-
Article
Open AccessThe clinical, immunological and genetic features of 12 Chinese patients with STAT3 mutations
Loss-of-function (LOF) mutations in signal transducer and activator of transcription 3 (STAT3) is one of the causes of STAT3 hyperimmunoglobulin E (IgE) syndrome (STAT3-HIES), while gain-of-function (GOF) muta...
-
Article
Open AccessLIG4 syndrome: clinical and molecular characterization in a Chinese cohort
DNA Ligase IV (LIG4) syndrome is a rare disease with few reports to date. Patients suffer from a broad spectrum of clinical features, including microcephaly, growth retardation, developmental delay, dysmorphic...
-
Article
Open AccessComplete regression of pulmonary squamous carcinoma in IPF following gemcitabine plus cisplatin: a case report and literature review
Lung cancer is one of the most common co-morbid conditions in patients with idiopathic pulmonary fibrosis (IPF) and negatively affects the prognosis of IPF; Current guidelines for the management of IPF do not ...
-
Reference Work Entry In depth
Survey on Machine-Learning Techniques in LTE Networks
-
Article
Low-Dose Pioglitazone does not Increase ROS Production in Chronic Granulomatous Disease Patients with Severe Infection
We sought to further investigate the efficacy and safety of pioglitazone for chronic granulomatous disease (CGD) patients with severe infection.
