26 Result(s)

Article

Aspirin prevents colorectal cancer by regulating the abundance of Enterococcus cecorum and TIGIT⁺Treg cells

Although aspirin can reduce the incidence of colorectal cancer (CRC), there is still uncertainty about its significance as a treatment for CRC, and the mechanism of aspirin in CRC is not well understood. In th...

**aojuan Yang, Yajuan Yan, Fengkui Wang, **hua Tian, Qian Cao… in Scientific Reports (2024)

Article

PMS2 amplification contributes brain metastasis from lung cancer

Lung adenocarcinoma metastasizing to the brain results in a notable increase in patient mortality. The high incidence and its impact on survival presents a critical unmet need to develop an improved understand...

Jianing Chen, Congli Hu, Hainan Yang, Li Wang… in Biological Procedures Online (2024)

Article

The activity and immune dynamics of PD-1 inhibition on high-risk pulmonary ground glass opacity lesions: insights from a single-arm, phase II trial

Immune checkpoint inhibitors targeting the programmed cell death-1 (PD-1) protein significantly improve survival in patients with advanced non-small-cell lung cancer (NSCLC), but its impact on early-stage grou...

Bo Cheng, Caichen Li, Jianfu Li, Longlong Gong… in Signal Transduction and Targeted Therapy (2024)

Article

Does caring for patients with advanced non-small cell lung cancer affect health-related quality of life of caregivers? A multicenter, cross-sectional study

Patients with advanced non-small cell lung cancer (NSCLC) mostly receive essential routine care and support from informal caregivers, who usually experience poorer health-related quality of life (HRQoL). The s...

Yi Yang, Liu Liu, Jia Chen, Yuying Gan, Chunxia Su, Haibo Zhang… in BMC Public Health (2024)

Article

Extracellular Vesicles for Drug Delivery in Cancer Treatment

Extracellular vesicles (EVs) are nanoscale vesicles derived from cells that mediate intercellular communication by transporting bioactive molecules. They play significant roles in various physiological and pat...

Li Wang, **n Yu, Juan Zhou, Chunxia Su in Biological Procedures Online (2023)

Article

Full spectrum flow cytometry-powered comprehensive analysis of PBMC as biomarkers for immunotherapy in NSCLC with EGFR-TKI resistance

Clinical studies suggest that immune checkpoint inhibitor (ICI) monotherapy has limited benefits in non-small cell lung cancer (NSCLC) patients after epidermal growth factor receptor-tyrosine kinase inhibitor ...

Juan Zhou, **angling Chu, **g Zhao, Mengqing **e, **g Wu… in Biological Procedures Online (2023)

Article

Fibronectin promotes tumor angiogenesis and progression of non-small-cell lung cancer by elevating WISP3 expression via FAK/MAPK/ HIF-1α axis and activating wnt signaling pathway

Fibronectin, an extracellular matrix protein, has been reported to be associated with heterogeneous cancer stemness, angiogenesis and progression in multiple cancer types. However, the roles and the underlying...

Fei Zhou, Jianguo Sun, Lingyun Ye, Tao Jiang, Wei Li… in Experimental Hematology & Oncology (2023)

Article

Measuring the indirect cost associated with advanced non-small cell lung cancer: a nationwide cross-sectional study in China

This study was conducted to estimate the indirect cost of locally advanced and metastatic non-small cell lung cancer (NSCLC) without sensitizing EGFR and ALK alterations in China and explore the predictors fro...

Yi Yang, Yu **a, Chunxia Su, Jia Chen… in Journal of Cancer Research and Clinical On… (2023)

Article

Mutational signatures of synchronous and metachronous brain metastases from lung adenocarcinoma

Brain metastasis (BM) is an important cause of mortality for cancer patients. Many patients were diagnosed with brain metastases at their first visit who have not received any treatment while a subset of patie...

Jianing Chen, Hainan Yang, Chao Zhao, Tao Lin, Da Liu… in Experimental Hematology & Oncology (2023)

Article

Correction to: The predictive value of inflammatory biomarkers for major pathological response in non-small cell lung cancer patients receiving neoadjuvant chemoimmunotherapy and its association with the immune-related tumor microenvironment: a multi-center study

Chongwu Li, Junqi Wu, Long Jiang, Lei Zhang, Jia Huang… in Cancer Immunology, Immunotherapy (2023)

Article

Influence of Exosomes on Astrocytes in the Pre-Metastatic Niche of Lung Cancer Brain Metastases

Lung cancer is the most common cause of cancer-related death globally. There are several reasons for this high mortality rate, including metastasis to multiple organs, especially the brain. Exosomes play a piv...

Lingyun Ye, Yinfei Wu, Juan Zhou, Mengqing **e… in Biological Procedures Online (2023)

Article

Increased blood-based intratumor heterogeneity (bITH) is associated with unfavorable outcomes of immune checkpoint inhibitors plus chemotherapy in non-small cell lung cancer

The combination of immune checkpoint inhibitors (ICIs) and chemotherapy has been the standard first-line treatment for advanced non-small cell lung cancer (NSCLC) patients with driver-gene negative. However, e...

Juan Zhou, Minwei Bao, Guanghui Gao, Yiran Cai, Lihong Wu, Lei Lei… in BMC Medicine (2022)

Article

Reduced frequencies of Foxp3⁺GARP⁺ regulatory T cells in COPD patients are associated with multi-organ loss of tissue phenotype

Expression of glycoprotein A dominant repeat (GARP) has been reported to occur only in activated human naturally occurring regulatory T cells (Tregs) and their clones, and not in activated effector T cells, in...

Jia Hou, **a Wang, Chunxia Su, Weirong Ma, **wei Zheng, **ahui Ge… in Respiratory Research (2022)

Article

Reactive oxygen species scavenging and inflammation mitigation enabled by biomimetic prussian blue analogues boycott atherosclerosis

As one typical cardiovascular disease, atherosclerosis severely endanger people’ life and cause burden to people health and mentality. It has been extensively accepted that oxidative stress and inflammation cl...

Yan Zhang, Yifei Yin, Wei Zhang, Hongyan Li, Taixia Wang… in Journal of Nanobiotechnology (2021)

Article

Single-cell profiling of tumor heterogeneity and the microenvironment in advanced non-small cell lung cancer

Lung cancer is a highly heterogeneous disease. Cancer cells and cells within the tumor microenvironment together determine disease progression, as well as response to or escape from treatment. To map the cell ...

Fengying Wu, Jue Fan, Yayi He, Anwen **ong, Jia Yu, Yixin Li… in Nature Communications (2021)

Article

Characterization of evolution trajectory and immune profiling of brain metastasis in lung adenocarcinoma

Characterizing the evolutionary trajectory and immune profiling of brain metastasis (BM) may provide insights in the development of novel therapeutic strategies. Here, we performed whole-exome sequencing and m...

Tao Jiang, Yan Yan, Kun Zhou, Chunxia Su, Shengxiang Ren, Nan Li… in npj Precision Oncology (2021)

Article

Genomic landscape and its correlations with tumor mutational burden, PD-L1 expression, and immune cells infiltration in Chinese lung squamous cell carcinoma

To depict the genomic landscape of Chinese early-stage lung squamous cell carcinoma (LUSC) and investigate its correlation with tumor mutation burden (TMB), PD-L1 expression, and immune infiltrates.

Tao Jiang, **peng Shi, Zhengwei Dong, Likun Hou… in Journal of Hematology & Oncology (2019)