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  1. No Access

    Protocol

    Introduction of shRNAs, miRNAs, or AntagomiRs into Primary Human Liver Cells Through Lentiviral Vectors

    RNA interference (RNAi) is a specific and efficient method to silence gene expression in mammalian cells. However, genetic manipulation of primary cells including human hepatocytes by RNAi remained challenging...

    Jessica K. Rieger, Maria Thomas in Lentiviral Vectors and Exosomes as Gene an… (2016)

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    Article

    Pregnane X receptor activation and silencing promote steatosis of human hepatic cells by distinct lipogenic mechanisms

    In addition to its well-characterized role in the regulation of drug metabolism and transport by xenobiotics, pregnane X receptor (PXR) critically impacts on lipid homeostasis. In mice, both ligand-dependent ...

    Andreas Bitter, Petra Rümmele, Kathrin Klein, Benjamin A. Kandel… in Archives of Toxicology (2015)