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Article
Open AccessMetabolomic profiling of upper GI malignancies in blood and tissue: a systematic review and meta-analysis
To conduct a systematic review and meta-analysis of case–control and cohort human studies evaluating metabolite markers identified using high-throughput metabolomics techniques on esophageal cancer (EC), cance...
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Article
Open AccessDie neue Weiterbildungsordnung – eine Herausforderung für die Viszeralchirurgie
Die neue kompetenzbasierte Weiterbildungsordnung (nWBO) für chirurgische Weiterbildungen wurde mittlerweile von allen deutschen Landesärztekammern übernommen.
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Article
Open AccessFistulising skin metastases in Crohn’s disease: a case report and review of the literature
Metastatic Crohn’s disease is a rare disorder characterized by various granulomatous skin lesions that occur independently of gastrointestinal tract involvement. However, currently there is no standardized car...
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Article
Open AccessREDISCOVER guidelines for borderline-resectable and locally advanced pancreatic cancer: management algorithm, unanswered questions, and future perspectives
The REDISCOVER guidelines present 34 recommendations for the selection and perioperative care of borderline-resectable (BR-PDAC) and locally advanced ductal adenocarcinoma of the pancreas (LA-PDAC). These guid...
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Article
Open AccessLaparoscopy training of novices with complex curved instruments using 2D- and 3D-visualization
Beside many advantages, disadvantages such as reduced degrees of freedom and poorer depth perception are still apparent in laparoscopic surgery. 3D visualization and the development of complex instruments are ...
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Article
Lebertransplantation in der Therapie nichtresektabler primärer und sekundärer Lebermalignome
Mit der zunehmenden Wirksamkeit systemischer Therapien spielt die Lebertransplantation nicht nur beim hepatozellulären Karzinom (HCC), sondern auch bei nichtresektablen intrahepatischen cholangiozellulären Kar...
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Article
Prophylaktische Chirurgie bei hereditären gastrointestinalen Dispositionssyndromen
Hereditäre gastrointestinale Tumordispositionssyndrome (HGTS) können ein hohes Krebsrisiko mit sich bringen und stellen für Patienten und behandelnde Ärzte eine große Herausforderung dar. Bei einigen erblichen...
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Article
Open AccessTGFβ signalling pathway impacts brain metastases profiles in locally advanced colorectal cancer
Colorectal Cancer (CRC) represents the third most common type of cancer in Germany and the second most common cancer-related cause of death worldwide. Distant metastases are still the main limit for patient su...
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Article
Open AccessClinical outcomes and perioperative morbidity and mortality following segmental resections of the colon for Crohn’s colitis
Crohn’s disease (CD) is a chronic inflammatory bowel disease of a multifactorial pathogenesis. Recently numerous genetic variants linked to an aggressive phenotype were identified, leading to a progress in the...
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Article
Open AccessTigecycline causes loss of cell viability mediated by mitochondrial OXPHOS and RAC1 in hepatocellular carcinoma cells
Despite recent advances in locoregional, systemic, and novel checkpoint inhibitor treatment, hepatocellular carcinoma (HCC) is still associated with poor prognosis. The feasibility of potentially curative live...
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Article
Chirurgische Therapie der Malignome bei chronisch-entzündlichen Darmerkrankungen
Das Risiko, an einem kolorektalen Karzinom (CRC) zu erkranken, ist sowohl bei der Colitis ulcerosa (CU) als auch bei Morbus Crohn (MC) deutlich erhöht. Der Hauptauslöser für die Entstehung von CRC bei chronisc...
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Article
Open AccessSPOCK2 gene expression is downregulated in pancreatic ductal adenocarcinoma cells and correlates with prognosis of patients with pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) represents a widespread form of malignant pancreatic neoplasms and a leading oncologic cause of death in Europe and the USA. Despite advances in understanding its molecu...
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Article
Open AccessA Retrospective Analysis of Biliary Tract Cancer Patients Presented to the Molecular Tumor Board at the Comprehensive Cancer Center Munich
With the rising importance of precision oncology in biliary tract cancer (BTC), the aim of this retrospective single-center analysis was to describe the clinical and molecular characteristics of patients with ...
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Article
Open AccessPhantom study on surgical performance in augmented reality laparoscopy
Only a few studies have evaluated Augmented Reality (AR) in in vivo simulations compared to traditional laparoscopy; further research is especially needed regarding the most effective AR visualization techniqu...
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Article
Open AccessPredictors of outcome for treatment of enterovaginal fistula
Enterovaginal fistulas represent a serious complication of various diseases and therapeutic procedures, often associated with complicated clinical courses and massive impairment of quality of life. As underlyi...
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Article
Open AccessGut Barrier Dysfunction and Bacterial Lipopolysaccharides in Colorectal Cancer
Inflammation is known to be an essential driver of various types of cancer. An increasing number of studies have suggested that the occurrence and development of colorectal cancer (CRC) are linked to the infl...
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Article
Open AccessTracking and evaluating motion skills in laparoscopy with inertial sensors
Analysis of surgical instrument motion is applicable in surgical skill assessment and monitoring of the learning progress in laparoscopy. Current commercial instrument tracking technology (optical or electroma...
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Article
Open AccessMolecular characteristics of microsatellite stable early-onset colorectal cancer as predictors of prognosis and immunotherapeutic response
The incidence of early-onset colorectal cancer (EO-CRC, in patients younger than 50) is increasing worldwide. The specific gene signatures in EO-CRC patients are largely unknown. Since EO-CRC with microsatelli...
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Article
Open AccessTPX2 expression as a negative predictor of gemcitabine efficacy in pancreatic cancer
Targeting protein for Xenopus kinesin-like protein 2 (TPX2) overexpression in human tumours is associated with increased malignancy. Its effect on gemcitabine resistance in pancreatic ductal adenocarcinoma (PD...
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Article
Open AccessSerum biomarker panel diagnostics in pancreatic ductal adenocarcinoma: the clinical utility of soluble interleukins, IFN-γ, TNF-α and PD-1/PD-L1 in comparison to established serum tumor markers
Novel biomarkers to better predict outcome and select the best therapeutic strategy for the individual patient are necessary for pancreatic ductal adenocarcinoma (PDAC).
