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Article
A computationally efficient approach for the design of population pharmacokinetic studies
A computationally efficient procedure was devised for designing experiments in which population pharmacokinetic parameters are estimated. The method, referred to as the large-sample approach, evaluates the var.....
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Article
Transdermal Delivery of Insulin Using Microneedles in Vivo
Purpose. The purpose of this study was to design and fabricate arrays of solid microneedles and insert them into the skin of diabetic hairless rats for transdermal delivery of insulin to lower blood glucose leve...
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Chapter and Conference Paper
Exhibition User Experience Research and Design for Applications of Context Awareness Technologies
Exhibition Context Awareness User Study and UI Design for Growth Markets is a collaborative practice of Tsinghua University Industrial Design Department and Nokia Research Center Bei**g. The task of the proje...
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Article
Open AccessVasoconstriction by Electrical Stimulation: New Approach to Control of Non-Compressible Hemorrhage
Non-compressible hemorrhage is the most common preventable cause of death on battlefield and in civilian traumatic injuries. We report the use of microsecond pulses of electric current to induce rapid constric...
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Chapter and Conference Paper
HiWi Project: High Efficiency Electric Drives
Vehicles develop their highest efficiency of around 93–95 % within a speed range of usually 1/4 to 1/3 of the maximum, whereas in real-life driving cycles the motor operates at a wider range of speeds and at p...
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Article
Upregulation of LYAR induces neuroblastoma cell proliferation and survival
The N-Myc oncoprotein induces neuroblastoma by regulating gene transcription and consequently causing cell proliferation. Paradoxically, N-Myc is well known to induce apoptosis by upregulating pro-apoptosis ge...
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Article
Open AccessScaPD: a database for human scaffold proteins
Scaffold proteins play a critical role in an increasing number of biological signaling processes, including simple tethering mechanism, regulating selectivity in pathways, sha** cellular behaviors. While man...
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Article
Granuloma Annulare: A Focused Review of Therapeutic Options
Granuloma annulare (GA) is a benign inflammatory disease associated with many conditions such as malignancy, trauma, thyroid disease, diabetes mellitus, and HIV infection. Common clinical subtypes include loca...
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Article
Open AccessDynamics of pore formation during laser powder bed fusion additive manufacturing
Laser powder bed fusion additive manufacturing is an emerging 3D printing technique for the fabrication of advanced metal components. Widespread adoption of it and similar additive technologies is hampered by ...
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Article
Open AccessNetwork-based method for drug target discovery at the isoform level
Identification of primary targets associated with phenotypes can facilitate exploration of the underlying molecular mechanisms of compounds and optimization of the structures of promising drugs. However, the l...
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Article
Open AccessSubsurface Cooling Rates and Microstructural Response during Laser Based Metal Additive Manufacturing
Laser powder bed fusion (LPBF) is a method of additive manufacturing characterized by the rapid scanning of a high powered laser over a thin bed of metallic powder to create a single layer, which may then be b...
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Article
A drug discovery platform to identify compounds that inhibit EGFR triple mutants
Receptor tyrosine kinases (RTKs) are transmembrane receptors of great clinical interest due to their role in disease. Historically, therapeutics targeting RTKs have been identified using in vitro kinase assays...
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Article
Open AccessMultimodal opioid-sparing pain management for emergent cesarean delivery under general anesthesia: a quality improvement project
Opioid-sparing multimodal analgesic approach has been shown to provide effective postoperative pain relief and reduce postoperative opioid consumption and opioid-associated adverse effects. While many studies ...
