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Article
Heartbeat-evoked neural response abnormalities in generalized anxiety disorder during peripheral adrenergic stimulation
Hyperarousal symptoms in generalized anxiety disorder (GAD) are often incongruent with the observed physiological state, suggesting that abnormal processing of interoceptive signals is a characteristic feature...
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Article
Open AccessExploring the role of neuronal-enriched extracellular vesicle miR-93 and interoception in major depressive disorder
Major depressive disorder (MDD) is associated with interoceptive processing dysfunctions, but the molecular mechanisms underlying this dysfunction are poorly understood. This study combined brain neuronal-enri...
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Article
Open AccessElevated serum leptin is associated with attenuated reward anticipation in major depressive disorder independent of peripheral C-reactive protein levels
Major depressive disorder (MDD) is associated with immunologic and metabolic alterations linked to central processing dysfunctions, including attenuated reward processing. This study investigated the associati...
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Article
Open AccessSelf-regulation of the posterior cingulate cortex with real-time fMRI neurofeedback augmented mindfulness training in healthy adolescents: A nonrandomized feasibility study
Mindfulness training (MT) promotes the development of one’s ability to observe and attend to internal and external experiences with objectivity and nonjudgment with evidence to improve psychological well-being...
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Article
Open AccessNeuronally-enriched exosomal microRNA-27b mediates acute effects of ibuprofen on reward-related brain activity in healthy adults: a randomized, placebo-controlled, double-blind trial
This double-blind, randomized, within-subjects design evaluated whether acute administration of an anti-inflammatory drug modulates neuron-specific, inflammation-modulating microRNAs linked to macroscopic chan...
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Article
Neurocircuitry of Mindfulness-Based Interventions for Substance Use Prevention and Recovery
Substance use disorders (SUD) are chronic and disabling conditions associated with significant public health burden. Current evidence-based treatments, while effective, have limited success and result in high ...
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Article
Open AccessLong-term stability of computational parameters during approach-avoidance conflict in a transdiagnostic psychiatric patient sample
Maladaptive behavior during approach-avoidance conflict (AAC) is common to multiple psychiatric disorders. Using computational modeling, we previously reported that individuals with depression, anxiety, and su...
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Article
Open AccessPerceptual insensitivity to the modulation of interoceptive signals in depression, anxiety, and substance use disorders
This study employed a series of heartbeat perception tasks to assess the hypothesis that cardiac interoceptive processing in individuals with depression/anxiety (N = 221), and substance use disorders (N = 136)...
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Article
Open AccessAttenuated reward activations associated with cannabis use in anxious/depressed individuals
Individuals with mood/anxiety disorders may use cannabis for “self-medication,” i.e., to induce positive mood or attenuate aversive mood states. However, little neurobiological evidence supports such use. The ...
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Article
When One Sibling has Autism: Adjustment and Sibling Relationship
The presence of autism spectrum disorder (ASD) in one sibling can impact typically develo** (TD) siblings’ adjustment and quality of the sibling relationship. The present study examined the impact of sibling...
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Article
Attenuated Insular Processing During Risk Predicts Relapse in Early Abstinent Methamphetamine-Dependent Individuals
There is some evidence that neuroimaging can be used to predict relapse among abstinent methamphetamine-dependent (MD) individuals. However, it remains unclear what cognitive and neural processes contribute to...
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Article
Effectiveness and Sustainability of School-Based Interventions for Youth with or at Risk for ADHD
In a pre–post design study, we examined the effectiveness and sustainability of a school mental health program for youth with or at-risk for ADHD (n = 41) when implemented over the course of 4 years by district-e...
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Article
Approach and Avoidance Profiles Distinguish Dimensions of Anxiety and Depression
Although a substantial body of research has examined the relationship between motivational systems and mood and anxiety disorders, there is disagreement among theorists regarding the nature of these relationsh...
