32 Result(s)
within
Jelle Matthijnssens
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Article
Open AccessCharacterization of the gut bacterial and viral microbiota in latent autoimmune diabetes in adults
Latent autoimmune diabetes in adults (LADA) is a heterogeneous disease characterized by autoantibodies against insulin producing pancreatic beta cells and initial lack of need for insulin treatment. The aim of...
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Article
Open AccessImpact of HIV infection and integrase strand transfer inhibitors-based treatment on the gut virome
Viruses are the most abundant components of the human gut microbiome with a significant impact on health and disease. The effects of human immunodeficiency virus (HIV) infection on gut virome has been scarcely...
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Article
Open AccessCold case: The disappearance of Egypt bee virus, a fourth distinct master strain of deformed wing virus linked to honeybee mortality in 1970’s Egypt
In 1977, a sample of diseased adult honeybees (Apis mellifera) from Egypt was found to contain large amounts of a previously unknown virus, Egypt bee virus, which was subsequently shown to be serologically relate...
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Article
A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate
The expanding pandemic of coronavirus disease 2019 (COVID-19) requires the development of safe, efficacious and fast-acting vaccines. Several vaccine platforms are being leveraged for a rapid emergency response1....
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Article
Open AccessSTAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters
Emergence of SARS-CoV-2 causing COVID-19 has resulted in hundreds of thousands of deaths. In search for key targets of effective therapeutics, robust animal models mimicking COVID-19 in humans are urgently nee...
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Article
Open AccessStable distinct core eukaryotic viromes in different mosquito species from Guadeloupe, using single mosquito viral metagenomics
Mosquitoes are the most important invertebrate viral vectors in humans and harbor a high diversity of understudied viruses, which has been shown in many mosquito virome studies in recent years. These studies g...
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Article
Evidence of zoonotic transmission of VP6 and NSP4 genes into human species A rotaviruses isolated in Pakistan in 2010
Introduction of animal group A rotavirus (RVA) gene segments into the human RVA population is a major factor sha** the genetic landscape of human RVA strains. The VP6 and NSP4 genes of 74 G/P-genotyped RVA i...
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Chapter
The Role of the Virome in the Gut-Liver Axis
Eukaryotic and prokaryotic viruses have been recognized as an important part and driver of the human gut microbiota within the past decades and are even present in greater numbers than bacteria. Unfortunately,...
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Article
Open AccessNanopore sequencing as a revolutionary diagnostic tool for porcine viral enteric disease complexes identifies porcine kobuvirus as an important enteric virus
Enteric diseases in swine are often caused by different pathogens and thus metagenomics are a useful tool for diagnostics. The capacities of nanopore sequencing for viral diagnostics were investigated here. Fi...
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Article
Complete coding sequence of a novel picorna-like virus in a blackbird infected with Usutu virus
Using random high-throughput RNA sequencing, the complete coding sequence of a novel picorna-like virus (a 9,228-nt contig containing 212,202 reads) was determined from a blackbird (Turdus merula) infected with U...
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Protocol
NetoVIR: Modular Approach to Customize Sample Preparation Procedures for Viral Metagenomics
The democratization of next-generation sequencing (NGS) technologies has enabled scientists to explore the diversity of microbial life in various ecological niches in an unpreceded depth. The role of viruses a...
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Article
Open AccessHighly diverse population of Picornaviridae and other members of the Picornavirales, in Cameroonian fruit bats
The order Picornavirales represents a diverse group of positive-stranded RNA viruses with small non-enveloped icosahedral virions. Recently, bats have been identified as an important reservoir of several highly p...
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Article
Open AccessErratum: Emergence of human G2P[4] rotaviruses containing animal derived gene segments in the post-vaccine era
Scientific Reports 6: Article number: 36841; published online: 14 November 2016; updated: 03 January 2017 The original version of this Article contained an error in the name of the first author Mark Zeller whi...
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Article
Open AccessEmergence of human G2P[4] rotaviruses containing animal derived gene segments in the post-vaccine era
The introduction of Rotarix into the Belgian immunization program in June 2006 coincided with an increase of the relative prevalence of G2P[4] strains. However, the genetic composition of these persistent G2P[...
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Article
Whole genomic characterization of Korean porcine G8P[7] reassortant rotaviruses
This study analyzed eleven genomic segments of three Korean porcine G8P[7] group A rotavirus (RVA) strains. Phylogenetically, these strains contained two bovine-like and nine porcine-like genomic segments. Eig...
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Article
Reassortment among picobirnaviruses found in wolves
We conducted a viral metagenomics study in diarrheic free-ranging wolves in Portugal, revealing for the first time the presence of reassortant picobirnaviruses. These viruses shared identical capsid segments t...
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Open AccessNovel highly divergent reassortant bat rotaviruses in Cameroon, without evidence of zoonosis
Bats are an important reservoir for zoonotic viruses. To date, only three RVA strains have been reported in bats in Kenya and China. In the current study we investigated the genetic diversity of RVAs in fecal ...
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Article
Open AccessExperimental feline enteric coronavirus infection reveals an aberrant infection pattern and shedding of mutants with impaired infectivity in enterocyte cultures
Feline infectious peritonitis (FIP) results from mutations in the viral genome during a common feline enteric coronavirus (FECV) infection. Since many virological and immunological data on FECV infections are ...
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Article
Open AccessDid Large-Scale Vaccination Drive Changes in the Circulating Rotavirus Population in Belgium?
Vaccination can place selective pressures on viral populations, leading to changes in the distribution of strains as viruses evolve to escape immunity from the vaccine. Vaccine-driven strain replacement is a m...
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Article
Open AccessModular approach to customise sample preparation procedures for viral metagenomics: a reproducible protocol for virome analysis
A major limitation for better understanding the role of the human gut virome in health and disease is the lack of validated methods that allow high throughput virome analysis. To overcome this, we evaluated th...
