9 Result(s)
within
Jean-Eudes Dazard
English
-
Article
Open AccessDrug perturbation gene set enrichment analysis (dpGSEA): a new transcriptomic drug screening approach
In this study, we demonstrate that our modified Gene Set Enrichment Analysis (GSEA) method, drug perturbation GSEA (dpGSEA), can detect phenotypically relevant drug targets through a unique transcriptomic enri...
-
Chapter
Unsupervised Bump Hunting Using Principal Components
Principal Components Analysis is a widely used technique for dimension reduction and characterization of variability in multivariate populations. Our interest lies in studying when and why the rotation to prin...
-
Article
Open AccessROCS: a Reproducibility Index and Confidence Score for Interaction Proteomics Studies
Affinity-Purification Mass-Spectrometry (AP-MS) provides a powerful means of identifying protein complexes and interactions. Several important challenges exist in interpreting the results of AP-MS experiments....
-
Article
Open AccessThe dynamics of E1A in regulating networks and canonical pathways in quiescent cells
Adenoviruses force quiescent cells to re-enter the cell cycle to replicate their DNA, and for the most part, this is accomplished after they express the E1A protein immediately after infection. In this context...
-
Article
Open AccessStudying genetic determinants of natural variation in human gene expression using Bayesian ANOVA
Standard genetic map** techniques scan chromosomal segments for location of genetic linkage and association signals. The majority of these methods consider only correlations at single markers and/or phenotyp...
-
Article
Genome-wide comparison of human keratinocyte and squamous cell carcinoma responses to UVB irradiation: implications for skin and epithelial cancer
To gain insight into the transformation of epidermal cells into squamous carcinoma cells (SCC), we compared the response to ultraviolet B radiation (UVB) of normal human epidermal keratinocytes (NHEK) versus t...
-
Article
P16INK4A is implicated in both the immediate and adaptative response of human keratinocytes to UVB irradiation
The p16INK4A-ARF locus plays a crucial role in the control of cellular proliferation via both the Rb and P53 pathways. We previously demonstrated that this locus is altered in human skin carcinomas. In the presen...
-
Article
Switch from p53 to MDM2 as differentiating human keratinocytes lose their proliferative potential and increase in cellular size
p53 transcription factor is mutated in most skin cell carcinomas and in more than 50% of all human malignancies. One of its transcriptional targets is MDM2, which in turn down-regulates p53. The role of the p5...
-
Article
MDM-2 protein is expressed in different layers of normal human skin
MDM-2 is one of the target genes of the p53 tumor suppressor protein. Its best characterized function is found in the inhibition of p53's ability to modulate transcription. Deregulated expression of MDM-2 could t...
