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  1. Article

    Open Access

    Methyl-qPCR: a new method to investigate Epstein–Barr virus infection in post-transplant lymphoproliferative diseases

    Epstein–Barr virus DNA viral load is used as a surrogate marker to start Rituximab in transplant recipients at risk of develo** PTLD. However, an elevated EBV DNAemia does not discriminate lymphoproliferatio...

    Chloé Borde, Frédérique Quignon, Corinne Amiel, Joël Gozlan… in Clinical Epigenetics (2022)

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    Article

    Emergence of autoantibodies to HMGB1 is associated with survival in patients with septic shock

    To assess the prevalence and predictive value of natural autoantibodies to high-mobility group box 1 (HMGB1) during sepsis.

    Stéphanie Barnay-Verdier, Lakhdar Fattoum, Chloé Borde… in Intensive Care Medicine (2011)

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    Article

    Mdm2: kee** p53 under control

    The Mdm2 gene is overexpressed in several human tumors. The oncogenic potential of Mdm2 is partially explained by the inhibition of the activity of the tumor suppressor protein p53. Determination of the three-dim...

    Jacques Piette, Henry Neel, Vincent Maréchal in Oncogene (1997)

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    Article

    MDM-2 protein is expressed in different layers of normal human skin

    MDM-2 is one of the target genes of the p53 tumor suppressor protein. Its best characterized function is found in the inhibition of p53's ability to modulate transcription. Deregulated expression of MDM-2 could t...

    Jean-Eudes Dazard, Didier Augias, Henry Neel, Valérie Mils, Vincent Marechal… in Oncogene (1997)

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    Article

    Conservation of structural domains and biochemical activities of the MDM2 protein from Xenopus laevis

    The Mdm2 gene is the best known cellular regulator of p53 tumor suppressor activity. We report here the cloning and characterization of Xdm2, its homolog in Xenopus laevis. Human, mouse and Xenopus MDM2 proteins ...

    Vincent Marechal, Brian Elenbaas, Lisa Taneyhill, Jacques Piette… in Oncogene (1997)