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Article
Open AccessExtracellular vesicle-mediated transfer of miRNA-1 from primary tumors represses the growth of distant metastases
Metastases originate from primary tumors and reach distant organs. Growing evidence suggests that metastases are under the control of primary tumors even outside the primary site; however, the mechanisms by wh...
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Article
Open AccessExosome proteomes reveal glycolysis-related enzyme enrichment in primary canine mammary gland tumor compared to metastases
Numerous evidence has highlighted the differences between primary tumors and metastases. Nonetheless, the differences in exosomal proteins derived from primary tumor and metastases remain elusive. Here, we aim...
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Article
Open AccessUbiquitin ligase RNF20 coordinates sequential adipose thermogenesis with brown and beige fat-specific substrates
In mammals, brown adipose tissue (BAT) and inguinal white adipose tissue (iWAT) execute sequential thermogenesis to maintain body temperature during cold stimuli. BAT rapidly generates heat through brown adipo...
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Article
Open AccessThe role and medical prospects of long non-coding RNAs in cardiovascular disease
Cardiovascular disease (CVD) has reached epidemic proportions and is a leading cause of death worldwide. One of the long-standing goals of scientists is to repair heart tissue damaged by various forms of CVD s...
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Article
Open AccessThe landscape of PBMC methylome in canine mammary tumors reveals the epigenetic regulation of immune marker genes and its potential application in predicting tumor malignancy
Genome-wide dysregulation of CpG methylation accompanies tumor progression and characteristic states of cancer cells, prompting a rationale for biomarker development. Understanding how the archetypic epigeneti...
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Article
Open AccessComparative oncology: overcoming human cancer through companion animal studies
Comparative oncology is a field of study that has been recently adopted for studying cancer and develo** cancer therapies. Companion animals such as dogs can be used to evaluate novel biomarkers or anticance...
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Article
Open AccessCardiomyocyte Death and Genome-Edited Stem Cell Therapy for Ischemic Heart Disease
Massive death of cardiomyocytes is a major feature of cardiovascular diseases. Since the regenerative capacity of cardiomyocytes is limited, the regulation of their death has been receiving great attention. Th...
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Article
Open AccessChemotherapy confers a conserved secondary tolerance to EGFR inhibition via AXL-mediated signaling bypass
Drug resistance remains the major culprit of therapy failure in disseminated cancers. Simultaneous resistance to multiple, chemically different drugs feeds this failure resulting in cancer relapse. Here, we in...
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Article
Correction to: Role of growth factors in hematopoietic stem cell niche
Unfortunately, this article is posted online with missing acknowledgement section.
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Article
Open AccessAlternative methylation of intron motifs is associated with cancer-related gene expression in both canine mammary tumor and human breast cancer
Canine mammary tumor (CMT) has long been considered as a good animal model for human breast cancer (HBC) due to their pathological and biological similarities. However, only a few aspects of the epigenome have...
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Article
Role of growth factors in hematopoietic stem cell niche
Hematopoietic stem cells (HSCs) produce new blood cells everyday throughout life, which is maintained by the self-renewal and differentiation ability of HSCs. This is not controlled by the HSCs alone, but rath...
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Article
Open AccessAuthor Correction: Methylation of LINE-1 in cell-free DNA serves as a liquid biopsy biomarker for human breast cancers and dog mammary tumors
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessExploring the key communicator role of exosomes in cancer microenvironment through proteomics
There have been many attempts to fully understand the mechanism of cancer behavior. Yet, how cancers develop and metastasize still remain elusive. Emerging concepts of cancer biology in recent years have focus...
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Article
Transposable element-mediated structural variation analysis in dog breeds using whole-genome sequencing
Naturally occurring diseases in dogs provide an important animal model for studying human disease including cancer, heart disease, and autoimmune disorders. Transposable elements (TEs) make up ~ 31% of the dog (C...
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Article
Open AccessMethylation of LINE-1 in cell-free DNA serves as a liquid biopsy biomarker for human breast cancers and dog mammary tumors
Breast cancer (BC) is one of the most common cancers in both women and female dogs. Methylation changes of LINE-1 have been reported in human cancers. The aim of this study was to determine the hypomethylation...
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Article
Open AccessCoronary stents with inducible VEGF/HGF-secreting UCB-MSCs reduced restenosis and increased re-endothelialization in a swine model
Atherosclerotic plaques within the vasculature may eventually lead to heart failure. Currently, cardiac stenting is the most effective and least invasive approach to treat this disease. However, in-stent reste...
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Article
Open AccessCCL4 enhances preosteoclast migration and its receptor CCR5 downregulation by RANKL promotes osteoclastogenesis
Chemokine CCL4 (MIP-1β) is released from osteoblast cells to restore the homeostasis of hematopoietic stem cells during the activation of bone marrow. In this study, we investigated the function of CCL4 and it...
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Article
Open AccessHedgehog-Interacting Protein (HIP) Regulates Apoptosis Evasion and Angiogenic Function of Late Endothelial Progenitor Cells
Late endothelial progenitor cells (LEPCs) are derived from mononuclear cells (MNCs) and are thought to directly incorporate into blood vessels and differentiate into mature endothelial cells (ECs). Using trans...
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Article
Open AccessThe Role of Nitrosamine (NNK) in Breast Cancer Carcinogenesis
Smoking cigarettes is one of the most concerning issues that leads to tobacco-related cancers and can even result in death. Therefore, these issues should be addressed with a great sense of urgency with low-co...
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Article
Open AccessFibroblast growth factor 2 supports osteoblastic niche cells during hematopoietic homeostasis recovery after bone marrow suppression
Hematopoietic stem cell (HSC) maintenance requires a specific microenvironment. HSC niches can be activated by tissue damaging chemotherapeutic drugs and various cell signaling molecules such as SDF-1 and FGF,...
