8 Result(s)
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Jasper A. Heinsbroek
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Article
Open AccessOxytocin and orexin systems bidirectionally regulate the ability of opioid cues to bias reward seeking
As opioid-related fatalities continue to rise, the need for novel opioid use disorder (OUD) treatments could not be more urgent. Two separate hypothalamic neuropeptide systems have shown promise in preclinical...
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Open AccessA common limiter circuit for opioid choice and relapse identified in a rodent addiction model
Activity in numerous brain regions drives heroin seeking, but no circuits that limit heroin seeking have been identified. Furthermore, the neural circuits controlling opioid choice are unknown. In this study, ...
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Article
Cocaine and sucrose rewards recruit different seeking ensembles in the nucleus accumbens core
Poorly regulated reward seeking is a central feature of substance use disorder. Recent research shows that rewarding drug-related experiences induce synchronous activation of a discrete number of neurons in th...
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Open AccessPrefrontal cortex neuronal ensembles encoding fear drive fear expression during long-term memory retrieval
The prefrontal cortex is an important regulator of fear expression in humans and rodents. Specifically, the rodent prelimbic (PL) prefrontal cortex drives fear expression during both encoding and retrieval of ...
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Open AccessA single, extinction-based treatment with a kappa opioid receptor agonist elicits a long-term reduction in cocaine relapse
Kappa opioid receptor (KOR) agonists have known anti-addiction properties and can reduce drug seeking. Their potential for clinical use has largely been daunted by their aversive properties mediated through p3...
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Accumbens Mechanisms for Cued Sucrose Seeking
Many studies support a perspective that addictive drugs usurp brain circuits used by natural rewards, especially for the dopamine-dependent reinforcing qualities of both drugs and natural rewards. Reinstated d...
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Perirhinal Cortex mGlu5 Receptor Activation Reduces Relapse to Methamphetamine Seeking by Restoring Novelty Salience
Rats that have self-administered methamphetamine (meth) under long access, but not short access, conditions do not recognize novel objects. The perirhinal cortex is critical for novelty detection, and perirhin...
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Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections
It is widely assumed that D1 and D2 dopamine receptor-expressing striatal neurons code for discrete pathways in the basal ganglia. Combining optogenetics and electrophysiology, the authors show that this outpu...
