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Article
Open AccessMicrobial modulation of host body composition and plasma metabolic profile
The gut microbiota is a critical mediator of nutrition and disease risk. Like most complex traits, the microbiome is under genetic regulation and differs between inbred strains of mice. We tested the effect of...
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Article
Cancer cachexia’s metabolic signature in a murine model confirms a distinct entity
Despite recent consensus definitions, lack of specific biomarkers remains a hurdle towards a more accurate and efficient diagnosis of cancer cachexia, distinguishing cachexia as a separate entity from other wa...
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Article
Stable isotope resolved metabolomics of primary human hepatocytes reveals a stressed phenotype
The development of techniques allowing the culturing of primary mammalian hepatocytes has provided great insights into liver physiology. For most applications, it is desirable for hepatocytes in culture to mim...
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Protocol
Noninvasive Fluxomics in Mammals by Nuclear Magnetic Resonance Spectroscopy
Metabolism is an interconnecting network of metabolite consumption and creation. Metabolomics has focused on metabolite concentrations in metabolic networks. Fluxomics is also required in the study of metaboli...
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Article
Metabolomic analysis of cancer cachexia reveals distinct lipid and glucose alterations
Cancer cachexia remains a challenging clinical problem with complex pathophysiology and unreliable diagnostic tools. A blood test to detect this metabolic derangement would aid in early treatment of these pati...
