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Article
Open AccessGs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake
Agouti-related peptide (AgRP) neurons of the hypothalamus play a key role in regulating food intake and body weight, by releasing three different orexigenic molecules: AgRP; GABA; and neuropeptide Y. AgRP neur...
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Article
Open AccessCorrection: Corrigendum: Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake
Nature Communications 7: Article number: 10268 (2016); Published: 8 January 2016; Updated: 3 March 2016 The financial support for this article was not fully acknowledged. The Acknowledgements should have inclu...
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Article
Open Accessβ-Arrestin-1 is required for adaptive β-cell mass expansion during obesity
Obesity is the key driver of peripheral insulin resistance, one of the key features of type 2 diabetes (T2D). In insulin-resistant individuals, the expansion of beta-cell mass is able to delay or even prevent ...
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Article
Open AccessClenbuterol exerts antidiabetic activity through metabolic reprogramming of skeletal muscle cells
Activation of the sympathetic nervous system causes pronounced metabolic changes that are mediated by multiple adrenergic receptor subtypes. Systemic treatment with β2-adrenergic receptor agonists results in mult...