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Open AccessB-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B-cell maturation antigen-immunoglobulin
B-lymphocyte stimulator (BLyS) and a proliferation-inducing ligand (APRIL) are members of the tumor necrosis factor (TNF) family that regulate B-cell maturation, survival, and function. They are overexpressed ...
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An APRIL to remember: novel TNF ligands as therapeutic targets
TNF family members have a multitude of crucial roles in the immune response, and numerous companies have invested millions of dollars to develop therapeutic dr...
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Erratum: Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice
Nature Immunology 5, 752–760 (2004). The published version of this article failed to include the microarray accession numbers. They are listed here: Geo microarray accession numbers. GSE1304, Control and Il31 ...
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Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice
T cell–derived cytokines are important in the development of an effective immune response, but when dysregulated they can promote disease. Here we identify a four-helix bundle cytokine we have called interleuk...
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Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function
Cytokines are important in the regulation of haematopoiesis and immune responses, and can influence lymphocyte development. Here we have identified a class I cytokine receptor that is selectively expressed in ...
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TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease
B cells are important in the development of autoimmune disorders by mechanisms involving disregulated polyclonal B-cell activation, production of pathogenic antibodies, and co-stimulation of autoreactive T cel...
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Non-Receptor Protein Tyrosine Kinases
Reversible phosphorylation of proteins has proved to be the most widely-employed regulatory mechanism governing cell behavior. Seminal studies performed in the 1960s by Edwin Krebs and colleagues on the regula...
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CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones
OCCUPANCY of the T-cell antigen receptor is insufficient to induce T-cell activation optimally; a second co-stimulatory signal is required1. Exposure of T-cell clones to complexes of antigen with major histocompa...