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  1. Article

    Open Access

    Enhanced immunogenicity of a functional enzyme by T cell epitope modification

    T helper epitopes are necessary for the induction of high titers of antigen-specific IgG antibodies. We are interested in the epitope modification of intact proteins as a method to enhance their immunogenicity...

    Jeanette M Mucha, Marcia M Stickler, AJ Poulose, Grant Ganshaw… in BMC Immunology (2002)

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    Antigen-specific human antibodies from mice comprising four distinct genetic modifications

    HUMAN sequence monoclonal antibodies, which in theory combine high specificity with low immunogenicity, represent a class of potential therapeutic agents. But nearly 20 years after Köhler and Milstein first de...

    Nils Lonberg, Lisa D. Taylor, Fiona A. Harding, Mary Trounstine, Kay M. Higgins… in Nature (1994)

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    Article

    CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

    OCCUPANCY of the T-cell antigen receptor is insufficient to induce T-cell activation optimally; a second co-stimulatory signal is required1. Exposure of T-cell clones to complexes of antigen with major histocompa...

    Fiona A. Harding, James G. McArthur, Jane A. Gross, David H. Raulet… in Nature (1992)