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Article
Open AccessMitochondrial impairment but not peripheral inflammation predicts greater Gulf War illness severity
Gulf War illness (GWI) is an important exemplar of environmentally-triggered chronic multisymptom illness, and a potential model for accelerated aging. Inflammation is the main hypothesized mechanism for GWI, ...
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Article
Open AccessUnsupervised learning for prognostic validity in patients with chronic pain in transdisciplinary pain care
Chronic pain is not a singular disorder and presents in various forms and phenotypes. Here we show data from a cohort of patients seeking treatment in a transdisciplinary pain clinic. Patients completed a mult...
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Article
Open AccessInducing Mild Traumatic Brain Injury in C. elegans via Cavitation-Free Surface Acoustic Wave-Driven Ultrasonic Irradiation
Mild traumatic brain injury is an all-too-common outcome from modern warfare and sport, and lacks a reproducible model for assessment of potential treatments and protection against it. Here we consider the use...
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Article
Open AccessAortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog
People heterozygous for an activating mutation in protein kinase G1 (PRKG1, p.Arg177Gln) develop thoracic aortic aneurysms and dissections (TAAD) as young adults. Here we report that mice heterozygous for the mut...
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Article
Aging increases the susceptibility of hepatic inflammation, liver fibrosis and aging in response to high-fat diet in mice
We aimed to investigate whether aging increases the susceptibility of hepatic and renal inflammation or fibrosis in response to high-fat diet (HFD) and explore the underlying genetic alterations. Middle (10 mo...
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Article
Electrophysiology and metabolism of caveolin-3-overexpressing mice
Caveolin-3 (Cav-3) plays a critical role in organizing signaling molecules and ion channels involved in cardiac conduction and metabolism. Mutations in Cav-3 are implicated in cardiac conduction abnormalities ...
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Delta Opioids in Protection of the Heart and Brain
Delta opioids have actions both centrally and peripherally to produce cell protection. This chapter will focus on the role of delta opioid receptors in protection of the heart and brain, the classic and non-cl...
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Article
Open AccessTraumatic brain injury enhances neuroinflammation and lesion volume in caveolin deficient mice
Traumatic brain injury (TBI) enhances pro-inflammatory responses, neuronal loss and long-term behavioral deficits. Caveolins (Cavs) are regulators of neuronal and glial survival signaling. Previously we showed...
