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  1. Article

    Open Access

    HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck

    Nef is an HIV-1 accessory protein essential for viral replication and AIDS progression. Nef interacts with a multitude of host cell signaling partners, including members of the Src kinase family. Nef preferent...

    Teodora Pene-Dumitrescu, Sherry T Shu, Thomas E Wales in BMC Chemical Biology (2012)

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    Article

    Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice

    The clinical translation of cationic α-helical antimicrobial peptides (AMPs) has been hindered by structural instability, proteolytic degradation and in vivo toxicity from nonspecific membrane lysis. Although ...

    Rida Mourtada, Henry D. Herce, Daniel J. Yin, Jamie A. Moroco in Nature Biotechnology (2019)