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Article
Open AccessImaging mass cytometry analysis of Becker muscular dystrophy muscle samples reveals different stages of muscle degeneration
Becker muscular dystrophy (BMD) is characterised by fiber loss and expansion of fibrotic and adipose tissue. Several cells interact locally in what is known as the degenerative niche. We analysed muscle biopsi...
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Article
Open AccessSeasonality and Lithic Investment in the Oldowan
Seasonality is a critical driver of resource availability within individual generations and is therefore likely to have exerted selective pressures on hominin evolution. Nonetheless, it has frequently been ove...
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Article
Open AccessDecoding the transcriptome of Duchenne muscular dystrophy to the single nuclei level reveals clinical-genetic correlations
Duchenne muscular dystrophy is a genetic disease produced by mutations in the dystrophin gene characterized by early onset muscle weakness leading to severe and irreversible disability. The cellular and molecu...
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Article
Open AccessDevelopment and validation of a hybrid simulator for ultrasound-guided laparoscopic common bile duct exploration
Ultrasound-guided laparoscopic common bile duct exploration (LCBDE) is the surgical management of choledocholithiasis. The procedure presents significant benefits to patients but still fails to be generalised ...
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Article
Open AccessThe National COVID Cancer Antibody Survey: a hyper-accelerated study proof of principle for cancer research
The COVID-19 pandemic has led to a range of novel and adaptive research designs. In this perspective, we use our experience coordinating the National COVID Cancer Antibody Survey to demonstrate how a balance b...
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Article
Index admission vs elective laparoscopic common bile duct exploration: a district general hospital experience over 6 years
Laparoscopic common bile duct exploration (LCBDE) is relatively a new approach for clearing choledocholithiasis. The aim of this study is to assess the safety of this approach to clearing common bile duct (CBD...
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Article
Open AccessComparative genomics of Acinetobacter baumannii and therapeutic bacteriophages from a patient undergoing phage therapy
In 2016, a 68-year-old patient with a disseminated multidrug-resistant Acinetobacter baumannii infection was successfully treated using lytic bacteriophages. Here we report the genomes of the nine phages used for...
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Article
Open AccessSensitive screening of single nucleotide polymorphisms in cell free DNA for diagnosis of gestational tumours
Tumours expressing human chorionic gonadotropin (hCG), the majority of which are difficult to biopsy due to their vascularity, have disparate prognoses depending on their origin. As optimal management relies o...
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Article
Childhood Mistreatment, PTSD, and Substance Use in Latinx: The Role of Discrimination in an Omitted-Variable Bias
Childhood mistreatment (CM) has been associated with adult posttraumatic disorder (PTSD) and substance use disorders (SUDs) in the general population. Few studies have examined the role of PTSD in the CM-SUD a...
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Article
Open AccessSpatially explicit analysis identifies significant potential for bioenergy with carbon capture and storage in China
As China ramped-up coal power capacities rapidly while CO2 emissions need to decline, these capacities would turn into stranded assets. To deal with this risk, a promising option is to retrofit these capacities t...
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Article
Open AccessA new alvarezsaurian theropod from the Upper Jurassic Shishugou Formation of western China
Alvarezsaurian dinosaurs, a group of bizarre theropods with greatly shortened and modified forelimbs, are known mostly from the Cretaceous of Asia and South America. Here we report a new alvarezsaurian, Shishugou...
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Article
Testing Restorative Narratives in a College Student Resilience Project
A new online program, The Student Resilience Project (https://strong.fsu.edu), explores how institutions can effectively communicate health and resilience in...
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Article
Open AccessAuthor Correction: Non-Invasive whole-body detection of complement activation using radionuclide imaging in a mouse model of myocardial ischaemia-reperfusion injury
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
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Article
Open AccessNon-Invasive whole-body detection of complement activation using radionuclide imaging in a mouse model of myocardial ischaemia-reperfusion injury
Complement activation is a recognised mediator of myocardial ischaemia-reperfusion-injury (IRI) and cardiomyocytes are a known source of complement proteins including the central component C3, whose activation...
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Chapter
Introduction
The importance of waste as a future feedstock for the chemical and allied industries is considered. In particular food supply chain waste is identified as a valuable source of useful chemical functions. While ...
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Chapter and Conference Paper
Interaction Analysis in Online Maths Human Tutoring: The Case of Third Space Learning
This ‘industry’ paper reports on the combined effort of researchers and industrial designers and developers to ground the automatic quality assurance of online maths human-to-human tutoring on best practices....
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Article
Open AccessOptical nanostructures in 2D for wide-diameter and broadband beam collimation
Eliminating curved refracting lensing components used in conventional projection, imaging and sensing optical assemblies, is critical to enable compactness and miniaturisation of optical devices. A suitable me...
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Chapter
Green and Sustainable Chemistry
The products of the chemical and pharmaceutical industries are indispensable for our high standard of living and health. Estimations say that about 100,000 chemicals are available on the market, mostly used in...
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Article
Open AccessCardiac myosin-binding protein C: a potential early biomarker of myocardial injury
Cardiac troponins are released and cleared slowly after myocardial injury, complicating the diagnosis of early, and recurrent, acute myocardial infarction. Cardiac myosin-binding protein C (cMyC) is a similarl...
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Article
A novel flexible hyper-redundant surgical robot: prototype evaluation using a single incision flexible access pelvic application as a clinical exemplar
The flexible endoscope is increasingly being considered as a surgical tool to enable innovative natural orifice or flexible access techniques. These experiences have exposed unique advantages but also signific...
