4 Result(s)
within
James A. Stewart Jr.
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Article
Coronary arterioles in type 2 diabetic (db/db) mice undergo a distinct pattern of remodeling associated with decreased vessel stiffness
Little is known about the impact of type 2 diabetes mellitus (DM) on coronary arteriole remodeling. The aim of this study was to determine the mechanisms that underlie coronary arteriole structural remodeling ...
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Article
Temporal alterations in cardiac fibroblast function following induction of pressure overload
Increases in cardiovascular load (pressure overload) are known to elicit ventricular remodeling including cardiomyocyte hypertrophy and interstitial fibrosis. While numerous studies have focused on the mechani...
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Article
Effects of elevated glucose levels on interactions of cardiac fibroblasts with the extracellular matrix
Exposure of fibroblasts to high glucose levels promotes a fibrotic response characterized by increased expression of extracellular matrix components including interstitial collagens. Little is known about the ...
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Article
The Dynamic Interaction Between Matrix Metalloproteinase Activity and Adverse Myocardial Remodeling
The process of cardiac remodeling in response to cardiac injury and/or persistent elevations in wall stress generally relates to the progressive changes that occur in ventricular chamber dimensions and the var...
