10 Result(s)
within
Jae-Ick Kim
English
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Article
Open AccessPLCγ1 in dopamine neurons critically regulates striatal dopamine release via VMAT2 and synapsin III
Dopamine neurons are essential for voluntary movement, reward learning, and motivation, and their dysfunction is closely linked to various psychological and neurodegenerative diseases. Hence, understanding the...
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Article
Open AccessmtIF3 is locally translated in axons and regulates mitochondrial translation for axonal growth
The establishment and maintenance of functional neural connections relies on appropriate distribution and localization of mitochondria in neurites, as these organelles provide essential energy and metabolites....
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Article
Open AccessO-GlcNAcylation in health and neurodegenerative diseases
O-GlcNAcylation is a posttranslational modification that adds O-linked β-N-acetylglucosamine (O-GlcNAc) to serine or threonine residues of many proteins. This protein modification interacts with key cellular path...
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Article
Open AccessDeletion of PLCγ1 in GABAergic neurons increases seizure susceptibility in aged mice
Synaptic inhibition plays a fundamental role in the information processing of neural circuits. It sculpts excitatory signals and prevents hyperexcitability of neurons. Owing to these essential functions, dysre...
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Article
Open AccessImpaired learning and memory in CD38 null mutant mice
CD38 is an enzyme that catalyzes the formation of cyclic ADP ribose and nicotinic acid adenine dinucleotide phosphate, both of which are involved in the mobilization of Ca2+ from intracellular stores. Recently, C...
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Article
Dynamic rewiring of neural circuits in the motor cortex in mouse models of Parkinson's disease
Using in vivo imaging, the authors explore how dopamine loss in Parkinson’s disease mouse models affects synaptic plasticity in motor cortex. They find that dopamine D1 and D2 receptor signaling distinctly regula...
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Article
Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function
Mutations in SHANK2 have been associated with autism spectrum disorders in humans; here, Shank2 mutant mice are shown to exhibit autistic-like behaviours that can be improved by restoring decreased NMDA receptor ...
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Chapter and Conference Paper
A Study on the Requirements for Designing Agent-Based Computer Generated Force
CGF (Computer Generated Forces) is known as a representation of constructive forces in a simulation environment which attempts to model human behavior. Currently, CGF deals with some extent on lower levels of ...
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Article
Open AccessGenetic enhancement of behavioral itch responses in mice lacking phosphoinositide 3-kinase-γ (PI3Kγ)
Phosphoinositide 3-kinases (PI3Ks) are important for synaptic plasticity and various brain functions. The only class IB isoform of PI3K, PI3Kγ, has received the most attention due to its unique roles in synapt...
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Article
PI3Kγ is required for NMDA receptor–dependent long-term depression and behavioral flexibility
This study examines the contribution of a specific phosphatidylinositol 3-kinase (PI3K) isoform, namely PI3Kγ, to hippocampal synaptic plasticity and behavior. The authors find that the loss of PI3Kγ can speci...
