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Article
Open AccessPhospholipase C-β3 is dispensable for vascular constriction but indispensable for vascular hyperplasia
Angiotensin II (AngII) induces the contraction and proliferation of vascular smooth muscle cells (VSMCs). AngII activates phospholipase C-β (PLC-β), thereby inducing Ca2+ mobilization as well as the production of...
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Article
Author Correction: Hypothalamic GABRA5-positive neurons control obesity via astrocytic GABA
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Article
Hypothalamic GABRA5-positive neurons control obesity via astrocytic GABA
The lateral hypothalamic area (LHA) regulates food intake and energy balance. Although LHA neurons innervate adipose tissues, the identity of neurons that regulate fat is undefined. Here we show that GABRA5-po...
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Article
Open AccessA new AMPK isoform mediates glucose-restriction induced longevity non-cell autonomously by promoting membrane fluidity
Dietary restriction (DR) delays aging and the onset of age-associated diseases. However, it is yet to be determined whether and how restriction of specific nutrients promote longevity. Previous genome-wide scr...
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Article
Open AccessKLHL3 deficiency in mice ameliorates obesity, insulin resistance, and nonalcoholic fatty liver disease by regulating energy expenditure
Obesity is a growing global epidemic that can cause serious adverse health consequences, including insulin resistance (IR) and nonalcoholic fatty liver disease (NAFLD). Obesity development can be attributed to...
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Article
Open AccessPancreatic cancer induces muscle wasting by promoting the release of pancreatic adenocarcinoma upregulated factor
Cancer cachexia is a highly debilitating condition characterized by weight loss and muscle wasting that contributes significantly to the morbidity and mortality of pancreatic cancer. The factors that induce ca...
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Article
Open AccessDeletion of PLCγ1 in GABAergic neurons increases seizure susceptibility in aged mice
Synaptic inhibition plays a fundamental role in the information processing of neural circuits. It sculpts excitatory signals and prevents hyperexcitability of neurons. Owing to these essential functions, dysre...
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Reference Work Entry In depth
Phosphoinositide-Specific Phospholipase C (PI-PLC)
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Article
Open AccessMemory and synaptic plasticity are impaired by dysregulated hippocampal O-GlcNAcylation
O-GlcNAcylated proteins are abundant in the brain and are associated with neuronal functions and neurodegenerative diseases. Although several studies have reported the effects of aberrant regulation of O-GlcNA...
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Article
Open AccessThe thalamic mGluR1-PLCβ4 pathway is critical in sleep architecture
The transition from wakefulness to a nonrapid eye movement (NREM) sleep state at the onset of sleep involves a transition from low-voltage, high-frequency irregular electroencephalography (EEG) waveforms to la...
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Article
Open AccessCorrection: Corrigendum: SREBP-2/PNPLA8 axis improves non-alcoholic fatty liver disease through activation of autophagy
Scientific Reports 6: Article number: 35732; published online: 21 October 2016; updated: 29 November 2016
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Article
Open AccessSREBP-2/PNPLA8 axis improves non-alcoholic fatty liver disease through activation of autophagy
Dysregulated autophagy is associated with steatosis and non-alcoholic fatty liver disease (NAFLD), however the mechanisms connecting them remain poorly understand. Here, we show that co-administration of lovas...
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Article
Open AccessResveratrol induces autophagy by directly inhibiting mTOR through ATP competition
Resveratrol (RSV) is a natural polyphenol that has a beneficial effect on health, and resveratrol-induced autophagy has been suggested to be a key process in mediating many beneficial effects of resveratrol, s...
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Living Reference Work Entry In depth
Phosphoinositide-Specific Phospholipase C (PI-PLC)
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Article
Obesity resistance and increased energy expenditure by white adipose tissue browning in Oga +/- mice
O-GlcNAcylation plays a role as a metabolic sensor regulating cellular signalling, transcription and metabolism. Transcription factors and signalling pathways related to metabolism are...
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Article
Open AccessDJ-1 contributes to adipogenesis and obesity-induced inflammation
Adipose tissue functions as an endocrine organ and the development of systemic inflammation in adipose tissue is closely associated with metabolic diseases, such as obesity and insulin resistance. Accordingly,...
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Chapter
Phospholipases in Health and Disease
Phospholipids are a class of complex lipids that are composed of two fatty acids, a glycerol unit, a phosphate group, and a polar molecule. Phospholipids include phosphatidylcholine, phosphatidylethanolamine, ...
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Article
DJ-1 promotes angiogenesis and osteogenesis by activating FGF receptor-1 signaling
Communication between osteoblasts and endothelial cells is essential for bone fracture repair, but the molecular identities of such communicating factors are not well defined. Here we identify DJ-1 as a novel ...
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Article
Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11
This report identifies PICT1 as a new regulator of p53. PICT1 binds the ribosomal protein RPL11 and prevents its release from the nucleolus, precluding RPL11 from inhibiting MDM2 activity. Loss of PICT1 increa...
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Article
Open AccessPhosphatidylinositol phosphates directly bind to neurofilament light chain (NF-L) for the regulation of NF-L self assembly
Phosphatidylinositol phosphates (PtdInsPs) are ubiquitous membrane phospholipids that play diverse roles in cell growth and differentiation. To clarify the regulation mechanism acting on neurofilament light ch...
