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Article
Open AccessDistinct baseline immune characteristics associated with responses to conjugated and unconjugated pneumococcal polysaccharide vaccines in older adults
Pneumococcal infections cause serious illness and death among older adults. The capsular polysaccharide vaccine PPSV23 and conjugated alternative PCV13 can prevent these infections; yet, underlying immunologic...
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Article
MEK inhibition reprograms CD8+ T lymphocytes into memory stem cells with potent antitumor effects
Regenerative stem cell–like memory (TSCM) CD8+ T cells persist longer and produce stronger effector functions. We found that MEK1/2 inhibition (MEKi) induces TSCM that have naive phenotype with self-renewability,...
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Article
Sestrins induce natural killer function in senescent-like CD8+ T cells
Aging is associated with remodeling of the immune system to enable the maintenance of life-long immunity. In the CD8+ T cell compartment, aging results in the expansion of highly differentiated cells that exhibit...
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Article
Open AccessThe lethal sex gap: COVID-19
While Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is disrupting lives across the globe for everyone, it has a more devastating impact on the hea...
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Article
Author Correction: Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza
In the version of this article initially published, a source of funding was not included in the Acknowledgements section. That section should include the following: P.J.M.O. was supported by EU FP7 PREPARE pro...
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Article
Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza
Transcriptional profiles and host-response biomarkers are used increasingly to investigate the severity, subtype and pathogenesis of disease. We now describe whole-blood mRNA signatures and concentrations of l...
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Article
Pathophysiology of T follicular helper cells in humans and mice
In this Review, Ueno, Vinuesa and Banchereau discuss the similarities and differences between mouse and human follicular helper T cells (TFH cells) and discuss their role in response to vaccines and in disease pa...
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Article
The cytokine TGF-β co-opts signaling via STAT3-STAT4 to promote the differentiation of human TFH cells
The factors that drive the differentiation of human follicular helper cells remain largely undefined. Ueno and colleagues show that TGF-β complements STAT3- and STAT4-activating cytokines to promote the initia...
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Chapter
Cancer Immunotherapy via Dendritic Cells
Owing to their properties, dendritic cells (DCs) are often called “nature’s adjuvants,” and thus have become the natural targets for antigen delivery. DCs provide an essential link between the innate and the a...
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Article
From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines
Feedback regulatory circuits provided by regulatory T cells (Treg cells) and suppressive cytokines are an intrinsic part of the immune system, along with effector functions. Here we discuss some of the regulatory...
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Chapter
Dendritic Cell Subsets as Vectors and Targets for Improved Cancer Therapy
Current active immunotherapy trials have shown durable tumor regressions in a fraction of patients. However, the clinical efficacy of current vaccines is limited, possibly because tumors skew the immune system...
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Article
Data management: it starts at the bench
Data management has been neglected but should be made an integral activity in all research laboratories. Chaussabel and colleagues discuss how to implement this at the bench.
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Article
Open AccessRibosomal protein mRNAs are translationally-regulated during human dendritic cells activation by LPS
Dendritic cells (DCs) are the sentinels of the mammalian immune system, characterized by a complex maturation process driven by pathogen detection. Although multiple studies have described the analysis of acti...
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Article
Influence of the transcription factor RORγt on the development of NKp46+ cell populations in gut and skin
Mouse lymphoid tissue–inducer (LTi) cells require the transcription factor RORγt. Cupedo's group identifies RORγt+ human LTi cell equivalents as committed natural killer cell precursors, and teams led by Vivier a...
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Article
Direct proteasome-independent cross-presentation of viral antigen by plasmacytoid dendritic cells on major histocompatibility complex class I
Although plasmacytoid dendritic cells (pDCs) respond to virus replication in a nonspecific way by producing large amounts of type I interferon, a rapid, direct function for pDCs in activating antiviral lymphoc...
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Chapter and Conference Paper
Dendritic Cells: Biological and Pathological Aspects
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Chapter
Dendritic Cell and Pathogen Interactions in the Subversion of Protective Immunity
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Article
Long-term outcomes in patients with metastatic melanoma vaccinated with melanoma peptide-pulsed CD34+ progenitor-derived dendritic cells
Between March 1999 and May 2000, 18 HLA-A*0201+ patients with metastatic melanoma were enrolled in a phase I trial using a dendritic cell (DC) vaccine generated by culturing CD34+ hematopoietic progenitors. This ...
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Article
Langerhans cells: daughters of monocytes
Precursors of specialized skin dendritic cells called Langerhans cells are derived from specific bone marrow–derived monocyte precursors that migrate to the skin and differentiate into these important immune s...
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Article
Human Dendritic Cell Subsets for Vaccination
TProtective immunity results from the interplay of antigen (Ag)-nonspecific innate immunity and Ag-specific adaptive immunity. The cells and molecules of the innate system employ non-clonal recognition pathway...