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Article
Unanswered questions following reports of secondary malignancies after CAR-T cell therapy
Reports of T cell malignancies after CAR-T cell therapy should be investigated, but existing data from follow-up studies suggest a low risk compared with other cancer treatments.
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Article
Open AccessA phase I study of an adenoviral vector delivering a MUC1/CD40-ligand fusion protein in patients with advanced adenocarcinoma
Cancer vaccines as immunotherapy for solid tumours are currently in development with promising results. We report a phase 1 study of Ad-sig-hMUC1/ecdCD40L (NCT02140996), an adenoviral-vector vaccine encoding t...
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Article
Open AccessFirst-in-Human Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Rapidly Developed SARS-CoV-2 Therapeutic Antibody, AOD01, in Healthy Adults
AOD01 is a novel, fully human immunoglobulin (Ig) G1 neutralizing monoclonal antibody that was developed as a therapeutic against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). This first-i...
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Article
Dendritic cell therapy with CD137L-DC-EBV-VAX in locally recurrent or metastatic nasopharyngeal carcinoma is safe and confers clinical benefit
Epstein-Barr virus (EBV) is associated with nasopharyngeal carcinoma (NPC), and provides a target for a dendritic cell (DC) vaccine. CD137 ligand (CD137L) expressed on antigen presenting cells, costimulates CD...
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Article
Open AccessBayesian analysis of cytokines and chemokine identifies immune pathways of HBsAg loss during chronic hepatitis B treatment
Our objective was to examine differences in cytokine/chemokine response in chronic hepatitis B(CHB) patients to understand the immune mechanism of HBsAg loss (functional cure) during antiviral therapy. We used...
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Article
Open AccessMet-Flow, a strategy for single-cell metabolic analysis highlights dynamic changes in immune subpopulations
A complex interaction of anabolic and catabolic metabolism underpins the ability of leukocytes to mount an immune response. Their capacity to respond to changing environments by metabolic reprogramming is cruc...
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Article
Open AccessInduction of Human T-cell and Cytokine Responses Following Vaccination with a Novel Influenza Vaccine
Cell mediated immunity plays a vital role in defense against influenza infection in humans. Less is known about the role of vaccine-induced cell mediated immunity and the cytokine responses elicited. We measur...
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Article
Open AccessChromosomal instability-induced senescence potentiates cell non-autonomous tumourigenic effects
Chromosomal instability (CIN), a high rate of chromosome loss or gain, is often associated with poor prognosis and drug resistance in cancers. Aneuploid, including near-polyploid, cells contain an abnormal num...
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Article
Open AccessBrief report: Decreased expression of CD244 (SLAMF4) on monocytes and platelets in patients with systemic lupus erythematosus
The signalling lymphocyte activation molecule (SLAM) family receptors play important roles in modulating immune responses. Previous studies in murine models and patients have suggested an association of the SL...
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Article
Whole metagenome profiling reveals skin microbiome-dependent susceptibility to atopic dermatitis flare
Whole metagenome analysis has the potential to reveal functional triggers of skin diseases, but issues of cost, robustness and sampling efficacy have limited its application. Here, we have established an alter...
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Protocol
Development of a Multiplex Bead-Based Assay to Monitor Dengue Virus Seroconversion
Dengue virus (DENV) envelope protein is responsible for viral attachment to host cells and as such is a target of neutralizing antibody responses. However, the presence of envelope-specific antibodies against ...
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Article
The specialized roles of immature and mature dendritic cells in antigen cross-presentation
Exogenous antigen cross-presentation is integral to the stimulation of cytotoxic T-lymphocytes against viruses and tumors. Central to this process are dendritic cells (DCs), which specialize in cross-presentat...
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Article
Open AccessClinical factors associated with a conservative gait pattern in older male veterans with diabetes
Patients with diabetes and peripheral neuropathy are at higher risk for falls. People with diabetes sometimes adopt a more conservative gait pattern with decreased walking speed, widened base, and increased do...
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Article
Direct proteasome-independent cross-presentation of viral antigen by plasmacytoid dendritic cells on major histocompatibility complex class I
Although plasmacytoid dendritic cells (pDCs) respond to virus replication in a nonspecific way by producing large amounts of type I interferon, a rapid, direct function for pDCs in activating antiviral lymphoc...
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Chapter
Dendritic Cell and Pathogen Interactions in the Subversion of Protective Immunity
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Article
Regulation and localization of endogenous human tristetraprolin
Tumor necrosis factor (TNF) has been implicated in the development and pathogenicity of infectious diseases and autoimmune disorders, such as septic shock and arthritis. The zinc-finger protein tristetraprolin...
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Article
Reflections on surgery as a career and its future
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Chapter
Prevention of Paraplegia Secondary to Operations on the Thoracic Aorta
In spite of vastly improved surgical techniques to successfully manage lesions of the thoracic aorta, paraplegia continues to be a serious postoperative complication of such procedures. While the incidence of ...
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Article
Current status of coronary artery surgery
After a decade of experience with direct coronary artery surgery, certain conclusions have been made regarding its benefits and indications. Conclusion one is that the operation is highly successful in elimina...
