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Article
Open AccessAuthor Correction: Prospective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients
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Article
Open AccessMUC5AC concentrations in lung lavage fluids are associated with acute lung injury after cardiac surgery
Heart surgery may be complicated by acute lung injury and adult respiratory distress syndrome. Expression and release of mucins MUC5AC and MUC5B in the lungs has been reported to be increased in acute lung inj...
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Article
Open AccessProspective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients
Data on convalescent plasma (CP) treatment in COVID-19 outpatients are scarce. We aimed to assess whether CP administered during the first week of symptoms reduced the disease progression or risk of hospitaliz...
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Article
Open AccessBone marrow transplantation induces changes in the gut microbiota that chronically increase the cytokine response pattern of splenocytes
Bone marrow transplantation (BMT) involves conditioning regimens which acutely induce side effects, including systemic inflammation, intestinal damage and shifts in the gut microbial composition, some of which...
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Article
Plasmapheresis to eliminate immunosuppressive alemtuzumab levels in a child with disseminated adenovirus infection after allogeneic stem cell transplantation
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Article
Open AccessIgG-Fc glycosylation before and after rituximab treatment in immune thrombocytopenia
The interactions of antibodies with myeloid Fcγ receptors and the complement system are regulated by an Asn297-linked glycan in the Fc portion of IgG. Alterations of serum IgG-Fc glycosylation have been report...
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Article
Open AccessIntramyocardial Injection of Autologous Bone Marrow-Derived Ex Vivo Expanded Mesenchymal Stem Cells in Acute Myocardial Infarction Patients is Feasible and Safe up to 5 Years of Follow-up
In experimental studies, mesenchymal stem cell (MSC) transplantation in acute myocardial infarction (AMI) models has been associated with enhanced neovascularization and myogenesis. Clinical data however, are ...
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Article
New gene functions in megakaryopoiesis and platelet formation
Platelets are the second most abundant cell type in blood and are essential for maintaining haemostasis. Their count and volume are tightly controlled within narrow physiological ranges, but there is only limi...
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Article
Open AccessIdentification of candidate genes linking systemic inflammation to atherosclerosis; results of a human in vivoLPS infusion study
It is widely accepted that atherosclerosis and inflammation are intimately linked. Monocytes play a key role in both of these processes and we hypothesized that activation of inflammatory pathways in monocytes...
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Article
Monophosphoryl lipid A plus IFNγ maturation of dendritic cells induces antigen-specific CD8+ cytotoxic T cells with high cytolytic potential
Dendritic cells (DCs) are promising antigen presenting cells for cancer treatment. Previously, we showed that the combination of monophosphoryl lipid A (MPLA) with IFNγ generates mature DCs that produce IL-12 ...
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Article
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium
Santhi Ganesh and colleagues report meta-analyses of genome-wide association studies of six erythrocyte traits within the CHARGE consortium, with replication in cohorts of the HaemGen consortium. They report 2...
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Article
Thrombus formation and platelet-vessel wall interaction in the nephrotic syndrome under flow conditions
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Endothelium in Hemostasis and Thrombosis
In the normal vasculature, blood platelets circulate freely through the vessels and no fibrin is formed. The capacity of the endothelium, which forms the inner lining of the blood vessel wall, to inhibit the a...
