Abstract
In the normal vasculature, blood platelets circulate freely through the vessels and no fibrin is formed. The capacity of the endothelium, which forms the inner lining of the blood vessel wall, to inhibit the activation of the coagulation cascade and to prevent platelet adhesion has been called “non-thrombogenicity”. The endothelium consists of a monolayer of cells, which have, under normal conditions, two different sites. The apical site faces the blood stream and is non-thrombogenic. On the basal site the cells synthesize an extracellular matrix, the subendothelium, which has thrombogenic properties. After contraction or desquamation of endothelial cells platelets rapidly adhere to the exposed subendothelium.
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© 1989 Plenum Press, New York
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de Groot, P.G., de Boer, H.C., Tijburg, P.N.M., Zwaginga, J.J. (1989). Endothelium in Hemostasis and Thrombosis. In: Westerhof, N., Gross, D.R. (eds) Vascular Dynamics. NATO ASI Series, vol 166. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7856-3_12
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DOI: https://doi.org/10.1007/978-1-4684-7856-3_12
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