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Article
Open AccessInterplay between YAP/TAZ and metabolic dysfunction-associated steatotic liver disease progression
Metabolic dysfunction-associated steatotic liver disease (MASLD) is becoming an increasingly pressing global health challenge, with increasing mortality rates showing an upward trend. Two million deaths occur ...
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Article
Open AccessHepatocyte GPCR signaling regulates IRF3 to control hepatic stellate cell transdifferentiation
Interferon Regulatory Factor 3 (IRF3) is a transcription factor that plays a crucial role in the innate immune response by recognizing and responding to foreign antigens. Recently, its roles in sterile conditi...
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Article
Open AccessMitochondrial stress activates YAP/TAZ through RhoA oxidation to promote liver injury
Yes-associated protein (YAP) and WW domain-containing transcription regulator protein 1 (WWTR1; also known as TAZ) are the main effectors of the Hippo pathway and their dysregulation contributes to diseases in...
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Article
Open AccessSteady-state memory-phenotype conventional CD4+ T cells exacerbate autoimmune neuroinflammation in a bystander manner via the Bhlhe40/GM-CSF axis
Memory-phenotype (MP) CD4+ T cells are a substantial population of conventional T cells that exist in steady-state mice, yet their immunological roles in autoimmune disease remain unclear. In this work, we unveil...
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Article
Open AccessERdj5 protects goblet cells from endoplasmic reticulum stress-mediated apoptosis under inflammatory conditions
Endoplasmic reticulum stress is closely associated with the onset and progression of inflammatory bowel disease. ERdj5 is an endoplasmic reticulum-resident protein disulfide reductase that mediates the cleavag...
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Article
Open AccessNuclear factor (erythroid-derived 2)-like 2 counter-regulates thymosin beta-4 expression and primary cilium formation for HeLa cervical cancer cell survival
We investigated the function of thymosin beta-4 (TB4) expression and primary cilium (PC) formation via the underlying Nrf2-dependent mechanism for cervical cancer cell (CC) survival under conditions of serum d...
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Protocol
CPP Applications in Immune Modulation and Disease Therapy
About 30 years ago, the discovery of CPP improved the therapeutic approach to treat diseases and extended the range of potential targets to intracellular molecules. There are potential drug candidates for FDA ...
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Article
Cell type-dependent function of LATS1/2 in cancer cell growth
The Hippo pathway controls organ size and tissue homeostasis, and its dysregulation often contributes to tumorigenesis. Extensive studies have shown that the Hippo pathway inhibits cell proliferation, and surv...
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Article
Open AccessRegulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis
Chitinase-3-like-1 (Chi3l1) is known to play a significant role in the pathogenesis of Type 2 inflammation and cancer. However, the function of Chi3l1 in T cell and its clinical implications are largely unknow...
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Article
Open AccessdNP2-ctCTLA-4 inhibits German cockroach extract-induced allergic airway inflammation and hyper-responsiveness via inhibition of Th2 responses
German cockroaches are major household allergens that can trigger allergic airway inflammatory diseases with sensitive T-cell responses. Although the use of immune modulatory biologics, such as antibodies, to ...
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Article
Open AccessHepcidin inhibits Smad3 phosphorylation in hepatic stellate cells by impeding ferroportin-mediated regulation of Akt
Hepatic stellate cell (HSC) activation on liver injury facilitates fibrosis. Hepatokines affecting HSCs are largely unknown. Here we show that hepcidin inhibits HSC activation and ameliorates liver fibrosis. W...
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Article
Farnesoid X receptor as a regulator of fuel consumption and mitochondrial function
Maintenance of energy homeostasis is crucial for survival of organism. There exists a close link between energy metabolism and cell survival, which are coordinately regulated by common signaling pathways. Farn...
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Article
Phytochemical regulation of Fyn and AMPK signaling circuitry
During the past decades, phytochemical terpenoids, polyphenols, lignans, flavonoids, and alkaloids have been identified as antioxidative and cytoprotective agents. Adenosine monophosphate-activated protein kin...
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Article
Open AccessdNP2 is a blood–brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis
Central nervous system (CNS)-infiltrating effector T cells play critical roles in the development and progression of multiple sclerosis (MS). However, current drugs for MS are very limited due to the difficult...
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Article
Cell membrane penetrating function of the nuclear localization sequence in human cytokine IL-1α
Cytokines are released from the cell, bind to their receptors, and affect cellular responses. The precursor form of interleukin 1 alpha (pIL-1α) has a nuclear localization sequence (NLS) that causes it to be l...
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Article
Electrical and optical characteristics of Co-sputtered amorphous Ce-doped indium-zinc-oxide thin-film transistors
We report the electrical and the optical characteristics of amorphous cerium-gallium-zinc-oxide (a-CIZO) thin-film transistors (TFTs) as a function of the cerium content inside the a-CIZO channel layers. The a...
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Article
Electrical features of an amorphous indium-gallium-zinc-oxide film transistor using a double active matrix with different oxygen contents
The electrical characteristics of amorphous indium-gallium-zinc-oxide (a-IGZO) thin film transistors (TFTs) are systematically studied using a double a-IGZO active layer that is composed of a-IGZO ...
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Article
Open AccessDetection of circulating tumor cells in patients with gastrointestinal tract cancer using RT-PCR and its clinical implications
To investigate the relationship between the presence of circulating tumor cells in different stages of gastrointestinal tract cancer and the subsequent relapse or distant metastasis, circulating levels of CEA ...
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Chapter
Regulation of Glutamine Synthetase Activity and Its Biosynthesis in Escherichia coli: Mediation by Three Cycles of Covalent Modification
Glutamine synthetase (GS), which catalyzes the first step of nitrogen assimilation in prokaryotes, occupies a central position in the regulation of nitrogen metabolism and is vigorously regulated in response t...
