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  1. Article

    Open Access

    dNP2 is a blood–brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis

    Central nervous system (CNS)-infiltrating effector T cells play critical roles in the development and progression of multiple sclerosis (MS). However, current drugs for MS are very limited due to the difficult...

    Sangho Lim, Won-Ju Kim, Yeon-Ho Kim, Sohee Lee, Ja-Hyun Koo… in Nature Communications (2015)

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    Article

    Cell membrane penetrating function of the nuclear localization sequence in human cytokine IL-1α

    Cytokines are released from the cell, bind to their receptors, and affect cellular responses. The precursor form of interleukin 1 alpha (pIL-1α) has a nuclear localization sequence (NLS) that causes it to be l...

    Ja-Hyun Koo, Heeseok Yoon, Won-Ju Kim, Sangho Lim… in Molecular Biology Reports (2014)