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Open AccessPerformance of an acoustic telemetry system in a large fishway
The ability to track fish in the vicinity of dams and detect the presence of fish in fishways (also referred to as fish ladders) is critical to understanding the migration biology of upstream migrating fish an...
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Book
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Protocol
Design and Preparation of Recombinant Antigens as Diagnostic Reagents in Solid-Phase Immunosorbent Assays
Analysis of the humoral immune response to infectious diseases has played, and will to continue to play, a key role in their diagnosis and immune surveillance. Although rapid genome detection methodologies, su...
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Book
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Protocol
Use of Recombinant Antigens as Diagnostic Reagents in Enzyme-Linked Immunosorbent Assays
The introduction of genetic engineering techniques has allowed the controlled and efficient production of recombinant proteins. This presents scientists with the opportunity to use a wide range of proteins for...
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Protocol
Recombinant Antigens in Viral Diagnosis
Traditionally, the accurate detection of viruses and the diagnosis of viral diseases has been difficult and expensive as viruses cannot be visualized by conventional light microscopy and need propagation in pr...
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Article
Funding for malaria genome sequencing
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Chapter
Oncogenes Involved in Chronic Myelocytic Leukemia
The Abelson strain of murine leukemia virus (MuLV) represents a recombinant between Moloney-MuLV and a cellular oncogene of mouse origin, c-abl (1). We have molecularly cloned human v-abl homologous sequences (hu...
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Chapter
Transforming Growth Factors Produced by Viral-Transformed and Human Tumor Cells
The isolation of retroviruses with acute transforming function has occurred with increasing frequency over the past few years. Such viruses represent genetic recombinants between host cellular sequences (oncog...
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Article
Localization of the c-abl oncogene adjacent to a translocation break point in chronic myelocytic leukaemia
The human c-abl oncogene maps within the region (q34-qter) of chromosome 9 which is translocated to chromosome 22, the Philadelphia (Ph′) chromosome, in chronic myelocytic leukaemia (CML). The position of the Ph′...
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Article
Translocation of c-abl oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia
The localization of cellular oncogenes near the break points of tumour-specific chromosomal aberrations suggests an involvement of these genes in the generation of neoplasms1,2. Recently, we demonstrated3 the tra...
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Article
Homology between phosphotyrosine acceptor site of human c-abl and viral oncogene products
The human homologues of several independent viral oncogenes, each of which encodes tyrosine-specific protein kinases, have been identified1,2. Of these, three (v-src, v-yes and v-fes/fps) are known to exhibit con...
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Article
A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia
The transforming genes of oncogenic retroviruses are homologous to a group of evolutionary conserved cellular onc genes1. The human cellular homologue (c-abl) of the transforming sequence of Abelson murine leukae...
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Article
Chromosomal localization of human cellular homologues of two viral oncogenes
Acute transforming RNA tumour viruses represent genetic recombinants between type C retro viral sequences and transformation-specific sequences of cellular origin. Of the known mammalian cell-derived transform...
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Article
Human transforming growth factors induce tyrosine phosphorylation of EGF receptors
Cultured cell lines of human tumour origin as well as cells transformed by various RNA tumour viruses secrete low molecular weight polypeptide transforming growth factors (TGFs)1,2. In addition to competing with ...
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Article
Feline sarcoma virus polyprotein P115 binds a host phosphoprotein in transformed cells
Several independent isolates of feline sarcoma virus (FeSV) have been described1–3. Such viruses are apparently derived by genetic recombination between feline leukaemia virus (FeLV) genomic RNA and host cellular...
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Article
Abelson murine leukaemia virus transformation involves loss of epidermal growth factor-binding sites
Malignant transformation by mammalian RNA sarcoma viruses has previously been shown to involve a reduction in receptor sites for a well characterized 6,000-molecular weight (MW) growth-promoting substance, des...
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Article
Immunoprevention of naturally occurring endogenous murine type-C RNA viruses
GENETIC sequences coding for type-C RNA viruses exist within the DNA of mouse cells1,2. In some inbred mouse strains endogenous viruses infectious for mouse cells are spontaneously activated and replicate in the ...
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Article
Endogenous C-type viral expression in primates
C-TYPE viruses are genetically transmitted in species representing several orders of vertebrates (for review see refs 1 and 2). So far the isolation of endogenous viruses of primates has been limited to specie...
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Article
RD-114 and feline leukaemia virus genome expression in natural lymphomas of domestic cats
THE widespread distribution of endogenous type C viral genetic sequences in many different vertebrate species1,2 is now well established. The biologic implications of the presence of such endogenous type C viral ...
