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Chapter
Transforming Growth Factors Produced by Viral-Transformed and Human Tumor Cells
The isolation of retroviruses with acute transforming function has occurred with increasing frequency over the past few years. Such viruses represent genetic recombinants between host cellular sequences (oncog...
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Article
Homology between phosphotyrosine acceptor site of human c-abl and viral oncogene products
The human homologues of several independent viral oncogenes, each of which encodes tyrosine-specific protein kinases, have been identified1,2. Of these, three (v-src, v-yes and v-fes/fps) are known to exhibit con...
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Article
Human transforming growth factors induce tyrosine phosphorylation of EGF receptors
Cultured cell lines of human tumour origin as well as cells transformed by various RNA tumour viruses secrete low molecular weight polypeptide transforming growth factors (TGFs)1,2. In addition to competing with ...
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Article
Feline sarcoma virus polyprotein P115 binds a host phosphoprotein in transformed cells
Several independent isolates of feline sarcoma virus (FeSV) have been described1–3. Such viruses are apparently derived by genetic recombination between feline leukaemia virus (FeLV) genomic RNA and host cellular...
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Article
Abelson murine leukaemia virus transformation involves loss of epidermal growth factor-binding sites
Malignant transformation by mammalian RNA sarcoma viruses has previously been shown to involve a reduction in receptor sites for a well characterized 6,000-molecular weight (MW) growth-promoting substance, des...
