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Article
Proportionally more deleterious genetic variation in European than in African populations
The analysis of genome-wide patterns of variation in human populations can provide genetic evidence of patterns of human migration and adaptation across the world. Two contrasting papers in this issue illustra...
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Article
Natural selection on protein-coding genes in the human genome
Are we still evolving? The simple answer is yes. A comparison of the sequences of over 11,000 genes from 39 human individuals and from chimpanzees reveals more than 1,139 genes that show evidence of either pos...
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Article
Cloning and endonuclease map** of the hepatitis B viral genome
THE virus that causes hepatitis B, or serum hepatitis, seems to infect only humans in nature, and experimental infection has been achieved in only a few additional mammals. The limited host range of the hepati...