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Article
No effects of pantoprazole on the pharmacokinetics of rosuvastatin in healthy subjects
Rosuvastatin disposition is modulated by the expression and activity of several membrane transporters including BCRP (ABCG2). The objective of our study was to investigate the effects of pantoprazole, a previo...
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Article
Low glycaemic index diet and disposition index in type 2 diabetes (the Canadian trial of Carbohydrates in Diabetes): a randomised controlled trial
We recently found that oral glucose tolerance over 1 year in type 2 diabetic patients declined to a significantly lesser degree on a low-glycaemic-index than on a reduced-carbohydrate diet. Here, we examined w...
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Article
Common polymorphisms of the PPAR-γ2 (Pro12Ala) and PGC-1α (Gly482Ser) genes are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial
We investigated the effects of the common polymorphisms in the peroxisome proliferator-activated receptor γ2 (PPAR-γ2; Pro12Ala) and in PPAR-γ coactivator 1α (PGC-1α; Gly482Ser) genes on the conversion from impai...
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Article
40th EASD Annual Meeting of the European Association for the Study of Diabetes
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Article
Acarbose for the prevention of Type 2 diabetes, hypertension and cardiovascular disease in subjects with impaired glucose tolerance: facts and interpretations concerning the critical analysis of the STOP-NIDDM Trial data
The STOP-NIDDM Trial has shown that acarbose treatment in subjects with impaired glucose tolerance is associated with a significant risk reduction in the development of diabetes, hypertension and cardiovascula...
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Article
35th Annual Meeting of the European Association for the Study of Diabetes
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Article
Small weight loss on long-term acarbose therapy with no change in dietary pattern or nutrient intake of individuals with non-insulin-dependent diabetes
OBJECTIVES: To see if the long-term treatment of non-insulin dependent diabetes (NIDDM) with the α-glucosidase inhibitor acarbose affects food intake and body weight. DESIGN: Randomized, double-blind, placebo-...
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Article
Fluoxetine improves insulin sensitivity in obese patients with non-insulin-dependent diabetes mellitus independently of weight loss
OBJECTIVE: To study the effect of fluoxetine, a specific serotonin reuptake inhibitor, on insulin sensitivity in obese patients with non-insulin-dependent diabetes mellitus (NIDDM) independently of its action ...
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Chapter and Conference Paper
Effects of Sucrose Meal on Insulin Requirement in IDDM and its Modulation by Acarbose
We have studied in patients with insulin-dependent diabetes mellitus (IDDM) the effects of a sucrose meal on glucose gut absorption, glucose turnover, insulin requirement, and the modulation of the latter by a...
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Chapter
Glucagon and Liver Glucose Output In Vivo
Human survival is dependent on maintaining a constant supply of fuel to various tissues of the body. During periods of feasting, ingested nutrients are stored in the liver, fat, and muscle. In between meals, a...