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  1. Article

    Protein kinase C isoforms α, δ and θ require insulin receptor substrate-1 to inhibit the tyrosine kinase activity of the insulin receptor in human kidney embryonic cells (HEK 293 cells)

    Protein kinase C (PKC) isoforms are potentially important as modulators of the insulin signalling chain and could be involved in the pathogenesis of cellular insulin resistance. We have previously shown that ...

    M. Kellerer, J. Mushack, E. Seffer, H. Mischak, A. Ullrich, H. U. Häring in Diabetologia (1998)

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  2. Article

    Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways

    We have recently shown that leptin mimicks insulin effects on glucose transport and glycogen synthesis through a phosphatidylinositol-3 (PI) kinase dependent pathway in C2C12 myotubes. The aim of the present stud...

    M. Kellerer, M. Koch, E. Metzinger, J. Mushack, E. Capp, H. U. Häring in Diabetologia (1997)

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  3. Article

    A 973 valine to methionine mutation of the human insulin receptor: interaction with insulin-receptor substrate-1 and Shc in HEK 293 cells

    A population-based study in the Netherlands has recently demonstrated that a mutation of the human insulin receptor (HIR-973 valine to methionine) is associated with hyperglycaemia and an increased prevalence...

    V. Strack, B. Bossenmaier, B. Stoyanov, J. Mushack, H. U. Häring in Diabetologia (1997)

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  4. Article

    Subcellular distribution of GLUT 4 in the skeletal muscle of lean type 2 (non-insulin-dependent) diabetic patients in the basal state

    Insulin resistance of the skeletal muscle is a key feature of Type 2 (non-insulin-dependent) diabetes mellitus. To determine whether a decrease of glucose carrier proteins or an altered subcellular distributio...

    B. Vogt, C. Mühlbacher, J. Carrascosa, B. Obermaier-Kusser, E. Seffer… in Diabetologia (1992)

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  5. Article

    Catecholamines and tumour promoting phorbolesters inhibit insulin receptor kinase and induce insulin resistance in isolated human adipocytes

    The effect of the catecholamine isoprenaline (10−5mol/l) and of the tumour promoting phorbolester tetradecanoyl-β-phorbol acetate (10−9mol/l) on insulin stimulated 3-O-methyl-glucose transport was studied in fres...

    B. Obermaier, B. Ermel, D. Kirsch, J. Mushack, E. Rattenhuber, E. Biemer… in Diabetologia (1987)

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