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Article
Open AccessAir pollution and trajectories of adolescent conduct problems: the roles of ethnicity and racism; evidence from the DASH longitudinal study
No known UK empirical research has investigated prospective associations between ambient air pollutants and conduct problems in adolescence. Ethnic minority children are disproportionately exposed to structura...
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Article
Open AccessDoes Treatment for Obstructive Sleep Apnoea Improve Arterial Stiffness? Evidence from Randomized Clinical Trials on Carotid-femoral Pulse Wave Velocity
Obstructive Sleep Apnoea (OSA) is a breathing disorder characterized by narrowing of the upper airway that impairs normal ventilation during sleep. OSA is a highly prevalent condition which is associated with ...
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Article
Open AccessP40: Does Arterial Ageing Differ Between Europeans and Japanese and Korean Patient Samples? Results from Current Uk Studies
Vascular stiffness has long been linked with the ageing process. However, it is only since the development of accurate methods for measuring arterial compliance that unravelling this relationship has become po...
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Article
Open AccessP161: Roles of Angiopoietins 1 and 2 on Arterial Function During A Treatment Trial in People with or At Risk of Diabetes
Vascular growth factors angiopoietin-1 (Ang1) and -2 (Ang2) regulate vascular permeability and inflammation, Ang2 likely as Ang1’s selective antagonist. Their role before or in type 2 diabetes (pre-&T2D) is un...
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Article
Open AccessP7.12 Circulating Vascular Growth Factors and Aortic Indices in Ghanaians with Diabetes and Hypertension
Impaired angiogenesis may be one mechanism linking large artery stiffness to organ damage. We investigated the relationship between arterial stiffness and regulators of angiogenesis as circulating vascular gro...
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Article
Open AccessP6.6 A Double Blind, Randomised Trial Investigating if Arterial Stiffness Can be Reduced Independently of Blood Pressure in Participants with or at Risk of Type 2 Diabetes
Arterial stiffness (AS) as pulse wave velocity (PWV), is a powerful independent predictor of cardiovascular events, and commonly complicates Type 2 diabetes (T2D). The VaSera machine measures cardiac (by 2nd s...
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Article
Open AccessP10.4 Early Life Predictors of Blood Pressure in Afro-Caribbean Young Adults: The Jamaica 1986 Birth Cohort Study
In this study we examined the effects of birth weight (BWT) and early life socioeconomic circumstances (SEC) on systolic and diastolic blood pressure (SBP, DBP) among Jamaican young adults.
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Article
P2.09: Chemical Fixation Alters the Macro- and Micro-Structure and Mechanical Behaviour of the Common Carotid Artery
Arterial stiffening is an important predictor of cardiovascular risk. In order to identify the pathogenic mechanisms it is necessary to characterise arterial micro-structure and emechanical properties. Here, w...
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Article
P3.18: Endothelial Function But Not in Intima-Media Thickness Relates to Renin Status in a Multi-Ethnic Group of Young Healthy Adults
Subjects of African and African-Caribbean ethnicity have been reported to have lower plasma renin activity (PRA), decreased endothelium-dependent vasomotor function and increased intima-media thickening relati...
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Article
P3.30: Difference in the Prevalence of Hypertension Using Standard Blood Pressure Measurement Compared to Ambulatory Blood Pressure Monitoring in Kilifi, Kenya
As sub Saharan Africa (sSA) goes through demographic and epidemiological transition, accurate data on disease prevalence are required to guide allocation of scarce health resources between declining but still ...
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Article
P3.03: International Comparison of Estimated Aortic Pulse Wave Velocity (APWV) in 3 Settings of African- and European- Origin Patients and Controls — Ghana, Britain and Barbados
In resource-poor settings, aPWV’s prognostic power, independent of blood pressure (BP), has potential as an intervention target against ‘hypertension’ and diabetes (T2DM). We compared simple determinants of aP...
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Article
P3.15: Arterial Stiffness in Non-Hypertensive Ghanaian Subjects with Type 2 Diabetes
Limited data exists on arterial stiffness in sub-Sahara Africa where diabetes and cardiovascular diseases are increasing rapidly. We aimed to compare the indices of arterial stiffness among type 2 diabetes (T2...
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Article
P3.17: Effect of Hypertension on Arterial Stiffness in Ghanaian Subjects with Type 2 Diabetes
Hypertension exacerbates cardiovascular disease in type 2 diabetes (T2DM) but the ACCORD trial suggested limited impact on CVS events by hypertensive treatment. Our hypothesis is that arterial stiffness, measu...
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Article
Open Access4.5 Localised Micromechanical Remodelling of the Aorta in a Model of Type 1 Diabetes
Whilst altered arterial stiffness is a hallmark of diabetes, the causative mechanisms and molecular targets remain poorly defined. Using a streptozotocin (STZ)-induced rat model of type 1 diabetes we have: i) ...
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Article
Open Access2.4 Vascular and Cardiac Structure and Function in Adult Survivors of Severe Acute Malnutrition
Severe acute malnutrition (SAM) has oedematous or non-oedematous phenotypes and their metabolic effects may persist into adulthood. We hypothesised that cardiovascular structure and function would differ betwe...
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Article
Open Access5.6: Independent Relation Between Ethnicity, Baseline Haemostatic Variables, Arterial Stiffness and Mortality: A 22-Year Follow-Up Study
To examine the relationship between haemostatic factors, pulse wave velocity (PWV), blood pressure (BP) and mortality in British Europeans, African-Caribbeans (AfC) and Gujarati Indians.
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Article
Open Access6.4: Cardiotrophin-1 Induces Structural and Mechanical Changes in Aorta
Cardiotrophin-1 (CT-1), a cytokine belonging to the interleukin-6 family, exerts proliferative and secretory effects in vascular smooth muscle cells. We investigated the morphological, micromechanical and mole...
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Article
Open AccessP5.10: Dissociation of Cardiac Remodelling and Aortic Stiffness Indices as of Cardiac/Vascular Risk, and Their Relationship to Vitamin D3
To investigate if concentric cardiac remodelling is related to central aortic Pulse Wave Velocity (aPWV) and to circulating vitamin D3, in men of different ethnic groups and cardiac/ vascular risk.
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Article
Open Access3.6 Nanomechanical Properties of a Model of Type 1 Diabetic Aorta
Although it is well established that in both Type 1 and Type 2 diabetes arterial stiffening occurs, the differential roles played by constitutive arterial components remain unknown. Here, we characterised the ...
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Article
The Effect of Type 1 Diabetes on the Structure and Function of Fibrillin Microfibrils
In Type 1 and 2 diabetes tissue stiffening is evident from measurements of the gross mechanical properties of the vasculature. Elastic fibers play an important role in the mechanical function of vascular tissu...
