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Article
Open AccessGlobal ocean wave fields show consistent regional trends between 1980 and 2014 in a multi-product ensemble
Historical trends in the direction and magnitude of ocean surface wave height, period, or direction are debated due to diverse data, time-periods, or methodologies. Using a consistent community-driven ensemble...
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Article
Transitional wave climate regions on continental and polar coasts in a warming world
Wave climate is a primary driver of coastal risk, yet how climate change is altering wave climate is not fully understood. Here we identify transitional wave climate regions, coastlines with a future change in...
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Article
Regulatory Controls for Buildings in Wildfire-Prone Areas of Australia
Australia has the most significant wildfire problem in Oceania, with in excess of 50,000 wildfires per annum on average, and an average of 500,000 km2 of land burnt by wildfires annually across the nation. Each y...
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Article
Open AccessImpact of rare decays t → ℓ′νbℓℓ and t → qq′bℓℓ on searches for top-associated physics
Searches for top quark-associated physics such as t ...
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Article
Open AccessP161: Roles of Angiopoietins 1 and 2 on Arterial Function During A Treatment Trial in People with or At Risk of Diabetes
Vascular growth factors angiopoietin-1 (Ang1) and -2 (Ang2) regulate vascular permeability and inflammation, Ang2 likely as Ang1’s selective antagonist. Their role before or in type 2 diabetes (pre-&T2D) is un...
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Article
Open AccessTranscriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines
Variation in the expression level and activity of genes involved in drug disposition and action (‘pharmacogenes’) can affect drug response and toxicity, especially when in tissues of pharmacological importance...
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Article
Open AccessP6.6 A Double Blind, Randomised Trial Investigating if Arterial Stiffness Can be Reduced Independently of Blood Pressure in Participants with or at Risk of Type 2 Diabetes
Arterial stiffness (AS) as pulse wave velocity (PWV), is a powerful independent predictor of cardiovascular events, and commonly complicates Type 2 diabetes (T2D). The VaSera machine measures cardiac (by 2nd s...
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Article
Open AccessTumour-infiltrating lymphocytes predict for outcome in HPV-positive oropharyngeal cancer
Human papillomavirus (HPV)-positive oropharyngeal cancer (OPSCC) is associated with improved survival compared with HPV-negative disease. However, a minority of HPV-positive patients have poor prognosis. Curre...
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Article
Allelic mRNA expression imbalance in C-type lectins reveals a frequent regulatory SNP in the human surfactant protein A (SP-A) gene
Genetic variation in C-type lectins influences infectious disease susceptibility but remains poorly understood. We used allelic mRNA expression imbalance (AEI) technology for surfactant protein (SP)-A1, SP-A2, SP...
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Article
Fine-scale spatial temperature patterns across a UK conurbation
The public health implications of a warming urban environment mean that appropriate action by planners, designers and health workers will be necessary to minimise risk under future climate scenarios. Data at a...
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Article
5 De betrouwbaarheid van de EMGsignalen van de bekkenbodemspieren, gemeten bij gezonde vrijwilligers met de Multiple Array Probe Leiden (MAPLe)
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Article
Comparison of atmospheric spectral radiance measurements from five independently calibrated systems
A variety of instruments have been developed over the past 50 years to measure spectral radiance in absolute units at UV and visible wavelengths with high spectral resolution. While there is considerable exper...
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Article
Open AccessThe context and potential of epigenetics in oncology
Cancer has long been known to be a disease caused by alterations in the genetic blueprint of cells. In the past decade it has become evident that epigenetic processes have a function, at least equally importan...
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Article
Open AccessA phase III trial comparing CHOP to PMitCEBO with or without G-CSF in patients aged 60 plus with aggressive non-Hodgkin's lymphoma
The management of older patients with aggressive non-Hodgkin's lymphoma presents a challenge to the physician. Age is a poor prognostic indicator, due to reduced ability to tolerate and maintain dose-intensive...
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Chapter and Conference Paper
EFFECT OF DYSTROPHIN GENE IMMOBILIZED NANOSTRUCTURED THERAPEUTIC TEMPLATES ON AGING SKELETAL MUSCLES
A preliminary investigation to articulate the effect of dystrophin immobilized on nanostructured therapeutic templates on aging skeletal muscles to cure Duchenne Muscular Dystrophy (DMD) is presented.
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Article
Sedation in haemofiltered patients: a retrospective study of compliance with the sedation policy
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Article
Open AccessA phase I dose-finding study of a combination of pegylated liposomal doxorubicin (Doxil), carboplatin and paclitaxel in ovarian cancer
Standard chemotherapy for advanced epithelial ovarian cancer is a combination of platinum-paclitaxel. One strategy to improve the outcome for patients is to add other agents to standard therapy. Doxil is activ...
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Article
Open AccessOxaliplatin and protracted venous infusion of 5-fluorouracil in patients with advanced or relapsed 5-fluorouracil pretreated colorectal cancer
The purpose of this study was to evaluate the activity and safety of oxaliplatin and protracted venous infusion of 5-fluorouracil (PVI 5-FU) in patients with advanced or relapsed 5-FU pretreated colorectal can...
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Article
Open AccessProtracted venous infusion 5-fluorouracil in combination with subcutaneous interleukin-2 and alpha-interferon in patients with metastatic renal cell cancer: a phase II study
Our purpose was to assess the activity of alpha-interferon (IFN-α), interleukin-2 (IL-2) and 5 fluorouracil (5FU) administered by protracted venous infusion (PVI) as opposed to bolus injection. 55 patients wit...
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Article
Open AccessA randomized phase II study of SRL172 (Mycobacterium vaccae) combined with chemotherapy in patients with advanced inoperable non-small-cell lung cancer and mesothelioma
Mycobacterial preparations have been used with limited success against cancer apart from superficial bladder cancer. Recently, a therapeutic vaccine derived from Mycobacterium vaccae has been given to patients wi...
